Jin H. Song, PhD

Assistant Professor/Research, Cellular and Molecular Medicine
Research Interests: 

Oncogene activation or tumor suppressor inactivation drives malignant transformation. Combined incidence of these genetic alterations accelerate tumorigenesis, which then further develop to invasive and metastatic cancer. To understand molecular mechanism and signal transduction underlying cancer initiation, progression and drug resistance, we take advanced technologies including gene expression array, antibody array, mass spectrometry, genetically engineered animal models and cell lines, analysis of clinical specimens, and small molecule drug screening. Research focuses on : (1) Oncogene activation or tumor suppressor inactivation promotes cancer development. We are investigating molecular mechanism(s) underlying the tumorigenesis by which Pim protein kinases to accelerate this process by examining metabolic changes, protein translation, and alteration in gene expression. (2) Translational and preclinical studies using in vitro cell assays and in vivo mouse models of tumors and metastases to evaluate small molecule protein kinase inhibitors to treat metastatic human cancers. (3) Studies to elucidate the role of posttranslational modifications of protein kinases in pathogenesis and disease progression of human cancers.

Molecular Medicine Grad Program: 
No

Bibliography

2016

Song, J. H., S. K. R. Padi, L. A. Luevano, M. D. Minden, D. J. DeAngelo, G. Hardiman, L. E. Ball, N. A. Warfel, and A. S. Kraft, "Insulin receptor substrate 1 is a substrate of the Pim protein kinases.", Oncotarget, 2016 Mar 4. PMID: 26956053
Warfel, N. A., A. G. Sainz, J. H. Song, and A. S. Kraft, "PIM kinase inhibitors kill hypoxic tumor cells by reducing Nrf2 signaling and increasing reactive oxygen species.", Mol Cancer Ther, 2016 May 16. PMID: 27196781

2015

Song, J. H., N. An, S. Chatterjee, E. Kistner-Griffin, S. Mahajan, S. Mehrotra, and A. S. Kraft, "Deletion of Pim kinases elevates the cellular levels of reactive oxygen species and sensitizes to K-Ras-induced cell killing.", Oncogene, vol. 34, issue 28, pp. 3728-36, 2015 Jul. PMCID: PMC4369476  PMID: 25241892

2014

Venkata, J. Kummetha, N. An, R. Stuart, L. J. Costa, H. Cai, W. Coker, J. H. Song, K. Gibbs, T. Matson, E. Garrett-Mayer, et al., "Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.", Blood, vol. 124, issue 12, pp. 1915-25, 2014 Sep 18. PMCID: PMC4168346  PMID: 25122609
Cen, B., Y. Xiong, J. H. Song, S. Mahajan, R. DuPont, K. McEachern, D. J. DeAngelo, J. E. Cortes, M. D. Minden, A. Ebens, et al., "The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling.", Mol Cell Biol, vol. 34, issue 13, pp. 2517-32, 2014 Jul. PMCID: PMC4054323  PMID: 24777602
Chatterjee, S., K. Thyagarajan, P. Kesarwani, J. H. Song, M. Soloshchenko, J. Fu, S. R. Bailey, C. Vasu, A. S. Kraft, C. M. Paulos, et al., "Reducing CD73 expression by IL1β-Programmed Th17 cells improves immunotherapeutic control of tumors.", Cancer Res, vol. 74, issue 21, pp. 6048-59, 2014 Nov 1. PMCID: PMC4216762  PMID: 25205101