My research interests center on the cell biology of antigen presentation within the immune system. We study a family of virus-encoded immune evasion molecules that co-opt host ubiquitin-dependent intracellular trafficking pathways to inhibit antigen presentation. These pathways are explored using biochemical and cell biological techniques.
Lonnie Lybarger, PhD
Associate Professor, Cellular and Molecular Medicine
Associate Professor, Immunobiology
Associate Professor, BIO5 Institute
Molecular Medicine Grad Program:
Lybarger, L., X. Wang, M. R. Harris, H. W. Virgin, and T. H. Hansen, "Virus subversion of the MHC class I peptide-loading complex.", Immunity, vol. 18, issue 1, pp. 121-30, 2003 Jan. PMID: 12530981
Lybarger, L., Y. Y. Yu, T. Chun, C. R. Wang, A. G. Grandea, L. Van Kaer, and T. H. Hansen, "Tapasin enhances peptide-induced expression of H2-M3 molecules, but is not required for the retention of open conformers.", J Immunol, vol. 167, issue 4, pp. 2097-105, 2001 Aug 15. PMID: 11489993