Keith A. Maggert, PhD

Associate Professor, Cellular and Molecular Medicine
Member, Genetics GIDP
Member, Cancer Biology GIDP
Research Interests: 

Many cancer cells - as cause or consequence of their disease state - undergo hypermutation and genomic instability.  My laboratory is interested in how and why these events occur, and how they enable cancer development and progression.  We focus on the repetitive ribosomal RNA genes to understand how epigenetic inheritance, gene regulation, and genome stability are linked together such that defects in one result in defects in the others.

Bibliography

2019

Maggert, K. A., "Stress: An evolutionary mutagen.", Proc Natl Acad Sci U S A, vol. 116, issue 36, pp. 17616-17618, 2019 Sep 03. PMID: 31434787
Valori, V., K. Tus, C. Laukaitis, D. T. Harris, L. LeBeau, and K. A. Maggert, "Human copy number is unstable in metastatic breast cancers.", Epigenetics, pp. 1-22, 2019 Aug 12. PMID: 31352858
Ji, J., X. Tang, W. Hu, K. A. Maggert, and Y. S. Rong, "The processivity factor Pol32 mediates nuclear localization of DNA polymerase delta and prevents chromosomal fragile site formation in Drosophila development.", PLoS Genet, vol. 15, issue 5, pp. e1008169, 2019 May. PMCID: PMC6542543  PMID: 31100062
Bughio, F., and K. A. Maggert, "The peculiar genetics of the ribosomal DNA blurs the boundaries of transgenerational epigenetic inheritance.", Chromosome Res, vol. 27, issue 1-2, pp. 19-30, 2019 03. PMCID: PMC6393165  PMID: 30511202
Bughio, F., G. R. Huckell, and K. A. Maggert, "Monitoring of switches in heterochromatin-induced silencing shows incomplete establishment and developmental instabilities.", Proc Natl Acad Sci U S A, 2019 Sep 16. PMID: 31527269

2015

Aldrich, J. C., and K. A. Maggert, "Transgenerational inheritance of diet-induced genome rearrangements in Drosophila.", PLoS Genet, vol. 11, issue 4, pp. e1005148, 2015 Apr. PMCID: PMC4401788  PMID: 25885886
Deans, C., and K. A. Maggert, "What do you mean, "epigenetic"?", Genetics, vol. 199, issue 4, pp. 887-96, 2015 Apr. PMCID: PMC4391566  PMID: 25855649

2014

Aldrich, J. C., and K. A. Maggert, "Simple quantitative PCR approach to reveal naturally occurring and mutation-induced repetitive sequence variation on the Drosophila Y chromosome.", PLoS One, vol. 9, issue 10, pp. e109906, 2014. PMCID: PMC4186871  PMID: 25285439

2012

Maggert, K. A., "Genetics: polymorphisms, epigenetics, and something in between.", Genet Res Int, vol. 2012, pp. 867951, 2012. PMCID: PMC3335516  PMID: 22567405

2011

Paredes, S., A. T. Branco, D. L. Hartl, K. A. Maggert, and B. Lemos, "Ribosomal DNA deletions modulate genome-wide gene expression: "rDNA-sensitive" genes and natural variation.", PLoS Genet, vol. 7, issue 4, pp. e1001376, 2011 Apr. PMCID: PMC3080856  PMID: 21533076