Many cancer cells - as cause or consequence of their disease state - undergo hypermutation and genomic instability. My laboratory is interested in how and why these events occur, and how they enable cancer development and progression. We focus on the repetitive ribosomal RNA genes to understand how epigenetic inheritance, gene regulation, and genome stability are linked together such that defects in one result in defects in the others.
Keith A. Maggert, Ph.D.
Associate Professor, Cellular and Molecular Medicine
Member, Genetics GIDP
Member, Cancer Biology GIDP
Maggert, K. A., "Stress: An evolutionary mutagen.", Proc Natl Acad Sci U S A, vol. 116, issue 36, pp. 17616-17618, 2019 Sep 03. PMID: 31434787
Valori, V., K. Tus, C. Laukaitis, D. T. Harris, L. LeBeau, and K. A. Maggert, "Human copy number is unstable in metastatic breast cancers.", Epigenetics, pp. 1-22, 2019 Aug 12. PMID: 31352858
Ji, J., X. Tang, W. Hu, K. A. Maggert, and Y. S. Rong, "The processivity factor Pol32 mediates nuclear localization of DNA polymerase delta and prevents chromosomal fragile site formation in Drosophila development.", PLoS Genet, vol. 15, issue 5, pp. e1008169, 2019 May. PMCID: PMC6542543 PMID: 31100062