Brett Colson, PhD

Assistant Professor, Cellular and Molecular Medicine
Research Interests: 

The research goal of my laboratory is to understand the molecular motions and interactions of proteins involved in regulating contractile function of healthy cardiac and skeletal muscle, to determine the culprits of contractile dysfunction and remodeling in muscle disorders and cardiovascular disease, and then apply these insights to design novel therapies. We use biophysical approaches, such as time-resolved spectroscopy with site-directed probes to assess protein structural dynamics and mechanical measurements of isolated muscle fibers to assess contractile force and kinetics, in order to establish structure-function relationships inherent to the molecular, biochemical, and physiological mechanisms.

Molecular Medicine Grad Program: 
Yes

Bibliography

2016

Colson, B. A., A. R. Thompson, M. L Espinoza-Fonseca, and D. D. Thomas, "Site-directed spectroscopy of cardiac myosin-binding protein C reveals effects of phosphorylation on protein structural dynamics.", Proc Natl Acad Sci U S A, vol. 113, issue 12, pp. 3233-8, 2016 Mar 22. PMCID: PMC4812748  PMID: 26908877

2015

Colson, B. A., K. J. Petersen, B. C. Collins, D. A. Lowe, and D. D. Thomas, "The myosin super-relaxed state is disrupted by estradiol deficiency.", Biochem Biophys Res Commun, vol. 456, issue 1, pp. 151-5, 2015 Jan 2. PMCID: PMC4276479  PMID: 25446114

2012

Colson, B. A., J. R. Patel, P. P. Chen, T. Bekyarova, M. I. Abdalla, C. W. Tong, D. P. Fitzsimons, T. C. Irving, and R. L. Moss, "Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium.", J Mol Cell Cardiol, vol. 53, issue 5, pp. 609-16, 2012 Nov. PMCID: PMC3472100  PMID: 22850286
Colson, B. A., I. N. Rybakova, E. Prochniewicz, R. L. Moss, and D. D. Thomas, "Cardiac myosin binding protein-C restricts intrafilament torsional dynamics of actin in a phosphorylation-dependent manner.", Proc Natl Acad Sci U S A, vol. 109, issue 50, pp. 20437-42, 2012 Dec 11. PMCID: PMC3528524  PMID: 23169656
Colson, B. A., S. J. Gruber, and D. D. Thomas, "Structural dynamics of muscle protein phosphorylation.", J Muscle Res Cell Motil, vol. 33, issue 6, pp. 419-29, 2012 Dec. PMCID: PMC3652605  PMID: 22930331