Darren Cusanovich, PhD, led a study published in the most recent issue of Cell presenting a single-cell atlas of chromatin (how the genome is packaged in the nucleus of a cell) patterns in adult mice based on data from almost 100,000 individual cells. Their work sheds light on how the various cell types present in mammals are able to accomplish such different functions while referencing the same genome. This resource may ultimately help us to understand precisely how human diseases develop and manifest in complex tissues.
Marco Padilla-Rodriguez, PhD – a recent CMM graduate from Dr. Gus Mouneimne’s lab- and colleagues have recently published a new study in Nature Communications highlighting estrogen’s dual effects of promoting tumor growth in estrogen receptor-positive (ER+) breast cancer, and suppressing tumor invasion through actin cytoskeletal remodeling.
Congratulations to CMM's own Diana Darnell, PhD for her promotion to full Professor, Educator Scholar Track!
CMM would like to extend a warm congratulations to Farah Bughio (Maggert lab), recipient of a 2018 Donald G. Sheer Memorial Fund travel grant! This fund provides stipends to graduate students to allow them to travel to scientific conferences and meetings in the health sciences to present their research. Great job, Farah!
Curtis Thorne, PhD, and colleagues published a new study in Developmental Cell describing a simple, scalable method to culture 2D enteroid monolayers that, surprisingly, recapitulates many of the features of in vivo intestinal tissue and can be used for high-throughput microscopy-based experiments. Using this system, they systematically perturb WNT and BMP signals to reveal a core morphogenic circuit that controls proliferation, tissue organization, and cell fate or the intestine.
CMM is delighted to welcome the following new PhD students who are entering the Graduate Program in Molecular Medicine: Alice Solomon, (Romanoski Lab), Austin Conklin (Romanoski Lab) and Rhye-Samuel Kanassatega (Colson Lab). We also extend a friendly welcome to the following Cancer Biology PhD students who will be working in labs with CMM faculty: Carly Cabel (Thorne Lab), Corbin Jensen (Warfel Lab) and Shekha Tahsin (Miranti Lab).