Curtis Thorne, PhD, and colleagues published a new study in Developmental Cell describing a simple, scalable method to culture 2D enteroid monolayers that, surprisingly, recapitulates many of the features of in vivo intestinal tissue and can be used for high-throughput microscopy-based experiments. Using this system, they systematically perturb WNT and BMP signals to reveal a core morphogenic circuit that controls proliferation, tissue organization, and cell fate or the intestine.
CMM is delighted to welcome the following new PhD students who are entering the Graduate Program in Molecular Medicine: Alice Solomon, (Romanoski Lab), Austin Conklin (Romanoski Lab) and Rhye-Samuel Kanassatega (Colson Lab). We also extend a friendly welcome to the following Cancer Biology PhD students who will be working in labs with CMM faculty: Carly Cabel (Thorne Lab), Corbin Jensen (Warfel Lab) and Shekha Tahsin (Miranti Lab).
Dr. Jean Wilson of Cellular & Molecular Medicine and Dr. Felicia Goodrum of Immunobiology have secured a 5 year grant from the National Institute of Allergy and Infectious Disease. This $1.9M grant is entitled “Cytomegalovirus Control of Host Membrane Trafficking.” Cytomegalovirus is a major cause of birth defects and increases risk for vascular disease and other age-related pathologies. These funds will be used to study how the virus co-opts host cell membrane trafficking to promote its survival and replication.
Tiffany McLamarrah, PhD, and colleagues publish new study on the regulation of centriole duplication. Centriole duplication is tightly regulated throughout the cell cycle to ensure one duplication event per centriole. McLamarrah et al. show that a stepwise pattern of Ana2 phosphorylation by Plk4 facilitates proper centriole duplication providing molecular insight into the assembly process of this organelle.
Dr. Henk Granzier was recently awarded a 4 year, $2 million grant from the National Heart, Lung, and Blood Institute (NHLBI). His grant, entitled “Titin-based adaptations of cardiac function” focuses on studying the mechanistic basis by with mutations in the giant protein titin result in dilated cardiomyopathy (DCM). DCM is a major cause of death, yet understanding the underlying mechanisms is still limited and treatment options are few at best. Mutations in titin are a common cause of DCM and the proposed work in this grant has high clinical relevance.
Congratulations to Gregory Rogers, who was recently awarded a 4 year, $1.2 million grant from the Nation Institute of General Medicine Sciences (NIGMS). His grant entitled “Inherent mechanism that govern centrosome function and duplication” focuses on dissecting evolutionarily conserved mechanisms that control the behaviors of centrosomes -- processes that, when dysfunctional, contribute to ciliopathy, birth defects and tumorigenesis.