• Brett Colson, PhD

    Deciphering the Structural Basis for Muscle Contraction at the Molecular Level


    Training Our Next Leaders in Biomedical Research

  • Greg Rogers, PhD

    Investigating Mechanisms of Genomic Integrity

  • Curtis Thorne, PhD

    Discovering Signals Controlling Cell Fate of Regenerative Tissues


    A Thriving Environment for Biomedical Discovery


    An Established Leader in Cutting-edge Research

  • Tom Doetschman, PhD

    Synergistic Activities of TGFbeta Deficiency and the Gut Microbiome in Colon Cancer

  • Samantha Harris, PhD

    Understanding Myosin Binding Protein-C in Health and Disease

  • Nathan Ellis, PhD

    Aberrant DNA Replication and Genomic Instability

  • Casey Romanoski, PhD

    Systems Genetics Approaches to Identify Mechanisms of Complex Diseases

  • Noel Warfel, PhD

    Modeling the Effects of Hypoxia on Cancer Cells and Tumor Angiogenesis

  • Gus Mouneimne, PhD

    Understanding How Cytoskeletal Architecture Regulates Cancer Metastasis

  • Jared Churko, PhD

    Informatics to Understand Cardiovascular Development and Disease Mechanisms

  • Keith Maggert, PhD

    Understanding the Origins of Genome Instability

  • Jean Wilson, PhD

    Cell biology of barrier function in inflammatory bowel diseases


Message from the Chair

The mission of the Department of Cellular and Molecular Medicine (CMM) is to provide pre- and post-doctoral, medical and graduate education in an interdisplinary environment through research activities, to advance knowledge of biological structure as related to function and disease from the molecular level to the whole organism.


Dr. Curtis Thorne publishes in Developmental Cell (March 19, 2018)

Curtis Thorne, PhD, and colleagues published a new study in Developmental Cell describing a simple, scalable method to culture 2D enteroid monolayers that, surprisingly, recapitulates many of the features of in vivo intestinal tissue and can be used for high-throughput microscopy-based experiments. Using this system, they systematically perturb WNT and BMP signals to reveal a core morphogenic circuit that controls proliferation, tissue organization, and cell fate or the intestine.

Welcome to our new students! (March 16, 2018)

CMM is delighted to welcome the following new PhD students who are entering the Graduate Program in Molecular Medicine: Alice Solomon, (Romanoski Lab), Austin Conklin (Romanoski Lab) and Rhye-Samuel Kanassatega (Colson Lab).   We also extend a friendly welcome to the following Cancer Biology PhD students who will be working in labs with CMM faculty: Carly Cabel (Thorne Lab), Corbin Jensen (Warfel Lab) and Shekha Tahsin (Miranti Lab). 

Wilson lab part of multi-PI grant from NIAID to study cytomegalovirus control of host membrane trafficking (March 8, 2018)

Dr. Jean Wilson of Cellular & Molecular Medicine and Dr. Felicia Goodrum of Immunobiology have secured a 5 year grant from the National Institute of Allergy and Infectious Disease.  This $1.9M grant is entitled “Cytomegalovirus Control of Host Membrane Trafficking.” Cytomegalovirus is a major cause of birth defects and increases risk for vascular disease and other age-related pathologies. These funds will be used to study how the virus co-opts host cell membrane trafficking to promote its survival and replication. 

Rogers lab publication appears in the Journal of Cell Biology (March 6, 2018)

Tiffany McLamarrah, PhD, and colleagues publish new study on the regulation of centriole duplication.  Centriole duplication is tightly regulated throughout the cell cycle to ensure one duplication event per centriole. McLamarrah et al. show that a stepwise pattern of Ana2 phosphorylation by Plk4 facilitates proper centriole duplication providing molecular insight into the assembly process of this organelle.

Professor Henk Granzier, PhD, awarded $2 million grant from the NHLBI to study titin-based adaptations of cardiac function (February 27, 2018)

Dr. Henk Granzier was recently awarded a 4 year, $2 million grant from the National Heart, Lung, and Blood Institute (NHLBI). His grant, entitled “Titin-based adaptations of cardiac function” focuses on studying the mechanistic basis by with mutations in the giant protein titin result in dilated cardiomyopathy (DCM). DCM is a major cause of death, yet understanding the underlying mechanisms is still limited and treatment options are few at best.  Mutations in titin are a common cause of DCM and the proposed work in this grant has high clinical relevance.

Professor Gregory Rogers, PhD, awarded $1.2 million NIH R01 grant to study centrosome function and duplication (February 23, 2018)

Congratulations to Gregory Rogers, who was recently awarded a 4 year, $1.2 million grant from the Nation Institute of General Medicine Sciences (NIGMS). His grant entitled “Inherent mechanism that govern centrosome function and duplication” focuses on dissecting evolutionarily conserved mechanisms that control the behaviors of centrosomes -- processes that, when dysfunctional, contribute to ciliopathy, birth defects and tumorigenesis.


An inspiration from THE DESERT – two team-building murals by CMM Faculty and Family. ​We had a blast at Creative Juice Bar on Tuesday evening (3/6/2018)!