Congratulations to CMM professor Henk Granzier, PhD, and the Granzier Lab, who were featured in an article for UA News! The article focuses on the Granzier Lab's discovery that titin regulates thick filament length in striated muscle. "Functionally and clinically, it is very important to regulate the thick filament precisely, otherwise muscles would not function well," said Dr. Granzier. "Biologists have always wondered what makes them so precisely structured." https://uanews.arizona.edu/story/introducing-titin-protein-rules-our-hea...
The Granzier Lab's findings were recently published in Nature Communications: https://www.nature.com/articles/s41467-017-01144-9
Congratulations to CMM Assistant Professor Casey Romanoski, PhD, as she was selected to showcase her lab's research at the 2017 American Society of Human Genetics meeting in Orlando, FL. The Romanoski Lab is using genetic differences between people's vascular cells to better define the cellular mechanisms that explain why some people are more prone to develop vascular diseases.
In recent study led by CMM Assistant Professor Noel Warfel, PhD, researchers identified PIM kinase expression as a novel mechanism of resistance to anti-angiogenic agents. Using models of prostate and colon cancer, they show that PIM is upregulated following treatment with anti-angiogenic therapies, which reduces the ability of these drugs to disrupt tumor vasculature. Moreover, combined inhibition of PIM and VEGF produces a synergistic anti-tumor response characterized by decreased proliferation, reduced tumor vasculature, and reduced metastasis. These findings, published in Clinical Cancer Research, show that targeting PIM kinase activity is a promising strategy to combat hypoxia-mediated therapeutic resistance. http://clincancerres.aacrjournals.org/content/early/2017/10/28/1078-0432.CCR-17-1318
Congratulations to our Cellular & Molecular Medicine faculty who were recipients of the 38th Annual College of Medicine Faculty Teaching Awards:
Dean's List for Excellence in Teaching (Year 1):
Maria H. Cuzak, PhD and Lonnie P. Lybarger, PhD
Outstanding Use of Education Technology:
Diana K. Darnell, PhD
Dr. Johan Lindqvist of the Granzier Lab was awarded a $117,000 research grant from A Foundation For Building Strength (AFBS) to investigate novel therapies to increase muscle force production in patients with nemaline myopathy by targeting the motor protein myosin. Congratulations, Dr. Lindqvist!