• Brett Colson, PhD

    Deciphering the Structural Basis for Muscle Contraction at the Molecular Level

  • LEADERS

    Training Our Next Leaders in Biomedical Research

  • RESEARCH

    An Established Leader in Cutting-edge Research

  • Noel Warfel, PhD

    Modeling the Effects of Hypoxia on Cancer Cells and Tumor Angiogenesis

  • Keith Maggert, PhD

    Understanding the Origins of Genome Instability

  • Tom Doetschman, PhD

    Synergistic Activities of TGFbeta Deficiency and the Gut Microbiome in Colon Cancer

  • Samantha Harris, PhD

    Understanding Myosin Binding Protein-C in Health and Disease

  • Gus Mouneimne, PhD

    Understanding How Cytoskeletal Architecture Regulates Cancer Metastasis

  • Greg Rogers, PhD

    Investigating Mechanisms of Genomic Integrity

  • Curtis Thorne, PhD

    Discovering Signals Controlling Cell Fate of Regenerative Tissues

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Message from the Chair

The mission of the Department of Cellular and Molecular Medicine (CMM) is to provide pre- and post-doctoral, medical and graduate education in an interdisplinary environment through research activities, to advance knowledge of biological structure as related to function and disease from the molecular level to the whole organism.

Announcements

Professor Henk Granzier, PhD, and Granzier Lab featured in UA News article

Congratulations to CMM professor Henk Granzier, PhD, and the Granzier Lab, who were featured in an article for UA News!  The article focuses on the Granzier Lab's discovery that titin regulates thick filament length in striated muscle.  "Functionally and clinically, it is very important to regulate the thick filament precisely, otherwise muscles would not function well," said Dr. Granzier. "Biologists have always wondered what makes them so precisely structured."  https://uanews.arizona.edu/story/introducing-titin-protein-rules-our-hea...

The Granzier Lab's findings were recently published in Nature Communications: https://www.nature.com/articles/s41467-017-01144-9

Assistant Professor Casey Romanoski, PhD, to present at 2017 American Society of Human Genetics Meeting

Congratulations to CMM Assistant Professor Casey Romanoski, PhD, as she was selected to showcase her lab's research at the 2017 American Society of Human Genetics meeting in Orlando, FL.  The Romanoski Lab is using genetic differences between people's vascular cells to better define the cellular mechanisms that explain why some people are more prone to develop vascular diseases.

Warfel Lab published in Clinical Cancer Research

In recent study led by CMM Assistant Professor, Noel Warfel PhD, researchers identified PIM kinase expression as a novel mechanism of resistance to anti-angiogenic agents. Using models of prostate and colon cancer, they show that PIM is upregulated following treatment with anti-angiogenic therapies, which reduces the ability of these drugs to disrupt tumor vasculature. Moreover, combined inhibition of PIM and VEGF produces a synergistic anti-tumor response characterized by decreased proliferation, reduced tumor vasculature, and reduced metastasis. These findings, published in Clinical Cancer Research, show that targeting PIM kinase activity is a promising strategy to combat hypoxia-mediated therapeutic resistance. http://clincancerres.aacrjournals.org/content/early/2017/10/28/1078-0432.CCR-17-1318

Congratulations CMM Fculty Teaching Award Winners!

Congratulations to our Cellular & Molecular Medicine  faculty who were recipients of the 38th Annual College of Medicine Faculty Teaching Awards:
Dean's List for Excellence in Teaching (Year 1):
Maria H. Cuzak, PhD and Lonnie P. Lybarger, PhD
Outstanding Use of Education Technology:
Diana K. Darnell, PhD

$117K Research grant awarded to Dr. Johan Lindqvist

Dr. Johan Lindqvist of the Granzier Lab was awarded a $117,000 research grant from A Foundation For Building Strength (AFBS) to investigate novel therapies to increase muscle force production in patients with nemaline myopathy by targeting the motor protein myosin.  Congratulations, Dr. Lindqvist!

Upcoming Events

Dec
12
2DRC/CMM Assistant Research Scientist Candidate Special Seminar: Darren Cusanovich “Resolving the developmental dynamics of chromatin accessibility with single-cell ATAC-seq”
Tuesday 2:00pm to 3:00pm
MRB Room 102

Dec
14
Associate Head Search Special Seminar: Hernando Sosa "Structural basis of microtubule depolymerization by kinesin-13s"
Thursday 4:00pm to 5:00pm