The overarching goal of my research program is to better understand the interaction between DNA variation and gene regulation. I study this interaction in settings of inflammation with application to complex diseases like atherosclerosis and hypertension. My research is predominantly focused on endothelial cells, which line blood vessels and are mediators of inflammation in the vessel wall. Using next-generation sequencing technologies, and a combination of experimental and computational approaches, we study how endothelial cells achieve context-appropriate expression patterns in healthy and inflammatory settings. By leveraging the interconnected relationship between DNA sequence, epigenetics, gene expression, and disease loci from genome-wide association studies, we aim to identify and interpret complex disease mechanisms.
Casey E. Romanoski, PhD
Assistant Professor, Cellular and Molecular Medicine
Assistant Professor & Research Fellow, BIO5 Institute
Molecular Medicine Grad Program:
Gosselin, D. *, V. M. * Link, C. E. * Romanoski, G. J. Fonseca, D. Z. Eichenfield, N. J. Spann, J. D. Stender, H. B. Chun, H. Garner, F. Geissmann, et al., "Environment drives selection and function of enhancers controlling tissue-specific macrophage identities.", Cell, vol. 159, issue 6, pp. 1327-40, 2014 Dec 4. PMCID: PMC4364385 PMID: 25480297
Romanoski, C. E., N. Che, F. Yin, N. Mai, D. Pouldar, M. Civelek, C. Pan, S. Lee, L. Vakili, W-P. Yang, et al., "Network for activation of human endothelial cells by oxidized phospholipids: a critical role of heme oxygenase 1.", Circ Res, vol. 109, issue 5, pp. e27-41, 2011 Aug 19. PMCID: PMC3163234 PMID: 21737788
Romanoski, C. E., S. Lee, M. J. Kim, L. Ingram-Drake, C. L. Plaisier, R. Yordanova, C. Tilford, B. Guan, A. He, P. S. Gargalovic, et al., "Systems genetics analysis of gene-by-environment interactions in human cells.", Am J Hum Genet, vol. 86, issue 3, pp. 399-410, 2010 Mar 12. PMCID: PMC2833388 PMID: 20170901