Casey E. Romanoski, PhD

Assistant Professor, Cellular and Molecular Medicine
BIO5 Fellow, BIO5 Institute
Faculty, Genetics Graduate Interdisciplinary Program
Member, Center for Applied Genetics and Genomic Medicine
Research Interests: 

The overarching goal of my research program is to better understand the interaction between DNA variation and gene regulation. I study this interaction in settings of inflammation with application to complex diseases like atherosclerosis and hypertension. My research is predominantly focused on endothelial cells, which line blood vessels and are mediators of inflammation in the vessel wall. Using next-generation sequencing technologies, and a combination of experimental and computational approaches, we study how endothelial cells achieve context-appropriate expression patterns in healthy and inflammatory settings. By leveraging the interconnected relationship between DNA sequence, epigenetics, gene expression, and disease loci from genome-wide association studies, we aim to identify and interpret complex disease mechanisms.

Molecular Medicine Grad Program: 
Yes

Bibliography

2017

Hogan, N. T., M. B. Whalen, L. K. Stolze, N. K. Hadeli, M. T. Lam, J. R. Springstead, C. K. Glass, and C. E. Romanoski, "Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells.", Elife, vol. 6, 2017 Jun 06. PMCID: PMC5461113  PMID: 28585919

2016

Thomas, G. D., R. N. Hanna, N. T. Vasudevan, A. A. Hamers, C. E. Romanoski, S. McArdle, K. D. Ross, A. Blatchley, D. Yoakum, B. A. Hamilton, et al., "Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6C(low) Monocytes while Preserving Macrophage Gene Function.", Immunity, vol. 45, issue 5, pp. 975-987, 2016 Nov 15. PMID: 27814941

2015

Vallim, T. Q. de Aguia, E. J. Tarling, H. Ahn, L. R. Hagey, C. E. Romanoski, R. G. Lee, M. J. Graham, H. Motohashi, M. Yamamoto, and P. A. Edwards, "MAFG is a transcriptional repressor of bile acid synthesis and metabolism.", Cell Metab, vol. 21, issue 2, pp. 298-310, 2015 Feb 03. PMCID: PMC4317590  PMID: 25651182
Romanoski, C. E., V. M. Link, S. Heinz, and C. K. Glass, "Exploiting genomics and natural genetic variation to decode macrophage enhancers.", Trends Immunol, vol. 36, issue 9, pp. 507-18, 2015 Sep. PMCID: PMC4548828  PMID: 26298065
Schwarz, F., O. M. T. Pearce, X. Wang, A. N. Samraj, H. Läubli, J. O. Garcia, H. Lin, X. Fu, A. Garcia-Bingman, P. Secrest, et al., "Siglec receptors impact mammalian lifespan by modulating oxidative stress.", Elife, vol. 4, 2015 Apr 07. PMCID: PMC4384638  PMID: 25846707
Romanoski, C. E., C. K. Glass, H. G. Stunnenberg, L. Wilson, and G. Almouzni, "Epigenomics: Roadmap for regulation.", Nature, vol. 518, issue 7539, pp. 314-6, 2015 Feb 19. PMID: 25693562

2014

Kaikkonen, M. U., H. Niskanen, C. E. Romanoski, E. Kansanen, A. M. Kivelä, J. Laitalainen, S. Heinz, C. Benner, C. K. Glass, and S. Ylä-Herttuala, "Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization.", Nucleic Acids Res, vol. 42, issue 20, pp. 12570-84, 2014 Nov 10. PMCID: PMC4227755  PMID: 25352550
Gosselin, D. *, V. M. * Link, C. E. * Romanoski, G. J. Fonseca, D. Z. Eichenfield, N. J. Spann, J. D. Stender, H. B. Chun, H. Garner, F. Geissmann, et al., "Environment drives selection and function of enhancers controlling tissue-specific macrophage identities.", Cell, vol. 159, issue 6, pp. 1327-40, 2014 Dec 4. PMCID: PMC4364385  PMID: 25480297

2013

Maubaret, C. G., K. D. Salpea, C. E. Romanoski, L. Folkersen, J. A. Cooper, C. Stephanou, K. Wah Li, J. Palmen, A. Hamsten, A. Neil, et al., "Association of TERC and OBFC1 haplotypes with mean leukocyte telomere length and risk for coronary heart disease.", PLoS One, vol. 8, issue 12, pp. e83122, 2013. PMCID: PMC3861448  PMID: 24349443
Shibata, N., A. F. Carlin, N. J. Spann, K. Saijo, C. S. Morello, J. G. McDonald, C. E. Romanoski, M. R. Maurya, M. U. Kaikkonen, M. T. Lam, et al., "25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.", J Biol Chem, vol. 288, issue 50, pp. 35812-23, 2013 Dec 13. PMCID: PMC3861632  PMID: 24189069
Heinz, S. *, C. E. * Romanoski, C. Benner, K. A. Allison, M. U. Kaikkonen, L. D. Orozco, and C. K. Glass, "Effect of natural genetic variation on enhancer selection and function.", Nature, vol. 503, issue 7477, pp. 487-92, 2013 Nov 28. PMCID: PMC3994126  PMID: 24121437
Kaikkonen, M. U., N. J. Spann, S. Heinz, C. E. Romanoski, K. A. Allison, J. D. Stender, H. B. Chun, D. F. Tough, R. K. Prinjha, C. Benner, et al., "Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.", Mol Cell, vol. 51, issue 3, pp. 310-25, 2013 Aug 08. PMCID: PMC3779836  PMID: 23932714
Erbilgin, A., M. Civelek, C. E. Romanoski, C. Pan, R. Hagopian, J. A. Berliner, and A. J. Lusis, "Identification of CAD candidate genes in GWAS loci and their expression in vascular cells.", J Lipid Res, vol. 54, issue 7, pp. 1894-905, 2013 Jul. PMCID: PMC3679391  PMID: 23667179

2012

Lee, S., K. G. Birukov, C. E. Romanoski, J. R. Springstead, A. J. Lusis, and J. A. Berliner, "Role of phospholipid oxidation products in atherosclerosis.", Circ Res, vol. 111, issue 6, pp. 778-99, 2012 Aug 31. PMCID: PMC3563283  PMID: 22935534
Lee, S., J. R. Springstead, B. W. Parks, C. E. Romanoski, R. Palvolgyi, T. Ho, P. Nguyen, A. J. Lusis, and J. A. Berliner, "Metalloproteinase processing of HBEGF is a proximal event in the response of human aortic endothelial cells to oxidized phospholipids.", Arterioscler Thromb Vasc Biol, vol. 32, issue 5, pp. 1246-54, 2012 May. PMCID: PMC3357069  PMID: 22402363

2011

Romanoski, C. E., N. Che, F. Yin, N. Mai, D. Pouldar, M. Civelek, C. Pan, S. Lee, L. Vakili, W-P. Yang, et al., "Network for activation of human endothelial cells by oxidized phospholipids: a critical role of heme oxygenase 1.", Circ Res, vol. 109, issue 5, pp. e27-41, 2011 Aug 19. PMCID: PMC3163234  PMID: 21737788
Kim, J. Brian, Y-R. Xia, C. E. Romanoski, S. Lee, YH. Meng, Y-S. Shi, N. Bourquard, K. Wei Gong, Z. Port, V. Grijalva, et al., "Paraoxonase-2 modulates stress response of endothelial cells to oxidized phospholipids and a bacterial quorum-sensing molecule.", Arterioscler Thromb Vasc Biol, vol. 31, issue 11, pp. 2624-33, 2011 Nov. PMCID: PMC3244174  PMID: 21836061

2010

Romanoski, C. E., S. Lee, M. J. Kim, L. Ingram-Drake, C. L. Plaisier, R. Yordanova, C. Tilford, B. Guan, A. He, P. S. Gargalovic, et al., "Systems genetics analysis of gene-by-environment interactions in human cells.", Am J Hum Genet, vol. 86, issue 3, pp. 399-410, 2010 Mar 12. PMCID: PMC2833388  PMID: 20170901

2008

Park, M. Soo, C. E. Romanoski, and B. M. Pryor, "A re-examination of the phylogenetic relationship between the causal agents of carrot black rot, Alternaria radicina and A. carotiincultae.", Mycologia, vol. 100, issue 3, pp. 511-27, 2008 May-Jun. PMID: 18751557

2007

Bennett, B. J., C. E. Romanoski, and A. J. Lusis, "Network-centered view of coronary artery disease.", Expert Rev Cardiovasc Ther, vol. 5, issue 6, pp. 1095-103, 2007 Nov. PMID: 18035925