Jean Wilson, PhD

Professor, Cellular and Molecular Medicine
Professor, BIO5 Institute
Research Interests: 

The ability of the epithelial cells to serve as a selective barrier to pathogens while absorbing nutrients is fundamental to their function. Tight junctions and associated polarity complexes are critical for selective permeability and maintenance of epithelial polarity. Our investigations of epithelial development and polarity focus on membrane trafficking to the junctions and apical membrane.

Molecular Medicine Grad Program: 
Yes

Bibliography

2017

Johnson, D. L., J. Wayt, J. M. Wilson, and J. G. Donaldson, "Arf6 and Rab22 mediate T cell conjugate formation by regulating clathrin-independent endosomal membrane trafficking.", J Cell Sci, 2017 Jun 05. PMID: 28584192
Parker, S. S., C. Cox, and J. M. Wilson, "Rabs set the stage for polarity.", Small GTPases, pp. 1-14, 2017 Jan 26. PMID: 28125340

2016

Lu, R., and J. M. Wilson, "Rab14 specifies the apical membrane through Arf6-mediated regulation of lipid domains and Cdc42.", Sci Rep, vol. 6, pp. 38249, 2016 Nov 30. PMCID: PMC5128791  PMID: 27901125

2015

Lu, R., L. Stewart, and J. M. Wilson, "Scaffolding protein GOPC regulates tight junction structure.", Cell Tissue Res, vol. 360, issue 2, pp. 321-32, 2015 May. PMCID: PMC4414737  PMID: 25616555
Cox, C.M.., E.K. Mandell, L. Stewart, R. Lu, D.L. Johnson, S.D.. McCarter, A. Tavares, R.. Runyan, S. Ghosh, and J.M.. Wilson, Endosomal regulation of contact inhibition through the AMOT:YAP pathway., , 2015.
Cox, C. M., E. K. Mandell, L. Stewart, R. Lu, D. L. Johnson, S. D. McCarter, A. Tavares, R. Runyan, S. Ghosh, and J. M. Wilson, "Endosomal regulation of contact inhibition through the AMOT:YAP pathway.", Mol Biol Cell, vol. 26, issue 14, pp. 2673-84, 2015 Jul 15. PMCID: PMC4501364  PMID: 25995376
Lu, R., D. Dalgalan, E. K. Mandell, S. S. Parker, S. Ghosh, and J. M. Wilson, "PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels.", Mol Biol Cell, vol. 26, issue 8, pp. 1523-31, 2015 Apr 15. PMCID: PMC4395131  PMID: 25694446

2014

Lu, R.., D..L.Johnson, L.. Stewart, K.. Waite, and J.. M. Wilson, Rab14 regulates epithelial lumen morphogenesis through regulation of claudin-2 trafficking. Molec Biol Cell 25:1744-54, , 2014.

2013

Parker, S. S., E. K. Mandell, S. M. Hapak, I. Y. Maskaykina, Y. Kusne, J-Y. Kim, J. K. Moy, P. A. St John, J. M. Wilson, K. M. Gothard, et al., "Competing molecular interactions of aPKC isoforms regulate neuronal polarity.", Proc Natl Acad Sci U S A, vol. 110, issue 35, pp. 14450-5, 2013 Aug 27. PMCID: PMC3761571  PMID: 23940317

2010

McCarter, S., D. Johnson, KN. Kitt, C. Donohue, AE. Adams, and JM. Wilson, Regulation of tight junction assembly and epithelial polarity by a resident protein of apical endosomes. Traffic 11:856-866, , 2010.

2008

Kitt, K. N., D. Hernández-Deviez, S. D. Ballantyne, E. T. Spiliotis, J. E. Casanova, and J. M. Wilson, "Rab14 regulates apical targeting in polarized epithelial cells.", Traffic, vol. 9, issue 7, pp. 1218-31, 2008 Jul. PMCID: PMC2773667  PMID: 18429929
Kitt, KN., D. Hernandez-Deviez, S. McCarter, E. Spiliotis, J.E. Casanova, and J.M. Wilson, The small GTPase Rab 14 regulates apical targeting. Traffic 9:1218-1231, , 2008.

2007

Hernández-Deviez, D., A. Mackay-Sim, and J. M. Wilson, "A Role for ARF6 and ARNO in the regulation of endosomal dynamics in neurons.", Traffic, vol. 8, issue 12, pp. 1750-64, 2007 Dec. PMID: 17897316

2004

Hernández-Deviez, D. J., M. G. Roth, J. E. Casanova, and J. M. Wilson, "ARNO and ARF6 regulate axonal elongation and branching through downstream activation of phosphatidylinositol 4-phosphate 5-kinase alpha.", Mol Biol Cell, vol. 15, issue 1, pp. 111-20, 2004 Jan. PMCID: PMC307532  PMID: 14565977

2002

Hernández-Deviez, D. J., J. E. Casanova, and J. M. Wilson, "Regulation of dendritic development by the ARF exchange factor ARNO.", Nat Neurosci, vol. 5, issue 7, pp. 623-4, 2002 Jul. PMID: 12032543

2001

Gokay, K. E., R. S. Young, and J. M. Wilson, "Cytoplasmic signals mediate apical early endosomal targeting of endotubin in MDCK cells.", Traffic, vol. 2, issue 7, pp. 487-500, 2001 Jul. PMID: 11422942

2000

Gokay, K. E., and J. M. Wilson, "Targeting of an apical endosomal protein to endosomes in Madin-Darby canine kidney cells requires two sorting motifs.", Traffic, vol. 1, issue 4, pp. 354-65, 2000 Apr. PMID: 11208120
Garver, W. S., R. A. Heidenreich, R. P. Erickson, M. A. Thomas, and J. M. Wilson, "Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments.", J Lipid Res, vol. 41, issue 5, pp. 673-87, 2000 May. PMID: 10787428
Wilson, J. M., M. de Hoop, N. Zorzi, B. H. Toh, C. G. Dotti, and R. G. Parton, "EEA1, a tethering protein of the early sorting endosome, shows a polarized distribution in hippocampal neurons, epithelial cells, and fibroblasts.", Mol Biol Cell, vol. 11, issue 8, pp. 2657-71, 2000 Aug. PMCID: PMC14947  PMID: 10930461

1999

Falk, T., W. S. Garver, R. P. Erickson, J. M. Wilson, and A. J. Yool, "Expression of Niemann-Pick type C transcript in rodent cerebellum in vivo and in vitro.", Brain Res, vol. 839, issue 1, pp. 49-57, 1999 Aug 21. PMID: 10482798

1997

Garver, W. S., R. P. Erickson, J. M. Wilson, T. L. Colton, G. S. Hossain, M. A. Kozloski, and R. A. Heidenreich, "Altered expression of caveolin-1 and increased cholesterol in detergent insoluble membrane fractions from liver in mice with Niemann-Pick disease type C.", Biochim Biophys Acta, vol. 1361, issue 3, pp. 272-80, 1997 Oct 24. PMID: 9375801

1995

Speelman, B. A., K. Allen, T. L. Grounds, M. R. Neutra, T. Kirchhausen, and J. M. Wilson, "Molecular characterization of an apical early endosomal glycoprotein from developing rat intestinal epithelial cells.", J Biol Chem, vol. 270, issue 4, pp. 1583-8, 1995 Jan 27. PMID: 7829488

1991

Wilson, J. M., J. A. Whitney, and M. R. Neutra, "Biogenesis of the apical endosome-lysosome complex during differentiation of absorptive epithelial cells in rat ileum.", J Cell Sci, vol. 100 ( Pt 1), pp. 133-43, 1991 Sep. PMID: 1795021

1990

Wilson, J. M., N. Fasel, and J. P. Kraehenbuhl, "Polarity of endogenous and exogenous glycosyl-phosphatidylinositol-anchored membrane proteins in Madin-Darby canine kidney cells.", J Cell Sci, vol. 96 ( Pt 1), pp. 143-9, 1990 May. PMID: 1973690

1989

Amerongen, H. M., J. A. Mack, J. M. Wilson, and M. R. Neutra, "Membrane domains of intestinal epithelial cells: distribution of Na+,K+-ATPase and the membrane skeleton in adult rat intestine during fetal development and after epithelial isolation.", J Cell Biol, vol. 109, issue 5, pp. 2129-38, 1989 Nov. PMCID: PMC2115838  PMID: 2553743

1987

Wilson, J. M., J. A. Whitney, and M. R. Neutra, "Identification of an endosomal antigen specific to absorptive cells of suckling rat ileum.", J Cell Biol, vol. 105, issue 2, pp. 691-703, 1987 Aug. PMCID: PMC2114780  PMID: 3305521