Research during the past 55 years has focused on: (a) the interactive role of bacterial toxins and toxicants (e.g., ethanol, acetaminophen, etc.) with sinusoidal lining cells in host defense mechanisms and pathophysiology of the liver; (b) the role of milk-borne substances in the development of the neonatal liver and intestine as well as their protection from injury, e.g., necrotizing enterocolitis; and (c) ageing of the hepatic microvascular system. McCuskey, R.S., N.W. Bethea, J. Wong, M.K. McCuskey, E. Abril, X. Wang, L.D. DeLeve. Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen. J. Hepatology 42: 371-377, 2005. Ito, Y., K.K. Sorensen, N.W. Bethea, D. Svistounov, M.K. McCuskey, B. Smedsrød, and R.S. McCuskey. Age-related changes in the hepatic microcirculation in mice. Exp. Gerontology 42: 789-797, 2007. McCuskey, R.S. The hepatic microcirculation in health and in response to toxicants. Anat. Rec. 291: 661-671, 2008. Svistounov, D., A. Oteiza, S.N. Zykova, K. Sørensen, P. McCourt, A. McLachlan, R.S. McCuskey, and B. Smedsrød. Hepatic disposition of advanced glycation and products during maturation and ageing. Exp. Gerontology 48: 549-556, 2013. Sørensen, K., J. Simon-Santamaria, R.S. McCuskey, and B. Smedsrød. The liver sinusoidal endothelial cells. Comp. Physiol. 5: 1751-1754, 2015.