Publications
2025
Iwanski, J. B., O. S. Lawal, W. T. Kwon, I. Vazquez, and J. M. Churko, "Minimal Component, Protein-Free, and Cost-effective Human Pluripotent Stem Cell Cardiomyocyte Differentiation.", Curr Protoc, vol. 5, issue 2, pp. e70099, 2025 Feb.
PMCID: PMC11834755 PMID: 39932462
Huang, K., M. Ashraf, L. Rohani, Y. Luo, A. Sacayanan, H. Huang, A. Haegert, S. Volik, F. Sar, S. LeBihan, et al., "Atrial Fibrillation Related Titin Truncation Is Associated With Atrial Myopathy in Patient-Derived Induced Pluripotent Stem Cell Disease Models.", Circ Genom Precis Med, vol. 18, issue 1, pp. e004412, 2025 Feb.
PMID: 39851047
Sukhavasi, K., G. Mocci, L. Ma, C. J. Hodonsky, E. Diez Benevante, L. Muhl, J. Liu, S. Gustafsson, B. Buyandelger, S. Koplev, et al., "Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques.", Nat Cardiovasc Res, vol. 4, issue 4, pp. 412-432, 2025 Apr.
PMCID: 9119695 PMID: 40211055
Subramanian, S. Peruvemba, M. Wojtkiewicz, F. Yu, C. Castro, E. N. Schuette, J. Rodriguez-Paar, J. Churko, P. Renavikar, D. Anderson, C. Mahr, et al., "Integrated multiomics reveals alterations in paucimannose and complex type N-glycans in cardiac tissue of COVID-19 patients.", Mol Cell Proteomics, pp. 100929, 2025 Feb 21.
PMID: 39988192
2024
Zhang, H., R. M. Mulqueen, N. Iannuzo, D. O. Farrera, F. Polverino, J. J. Galligan, J. G. Ledford, A. C. Adey, and D. A. Cusanovich, "txci-ATAC-seq: a massive-scale single-cell technique to profile chromatin accessibility.", Genome Biol, vol. 25, issue 1, pp. 78, 2024 Mar 22.
PMCID: PMC10958877 PMID: 38519979
Schaunaman, N., D. Cervantes, T. Nichols, M. Numata, J. G. Ledford, M. Kraft, and H. Wei Chu, "Cooperation of immune regulators Tollip and surfactant protein A inhibits influenza A virus infection in mice.", Respir Res, vol. 25, issue 1, pp. 193, 2024 May 03.
PMCID: PMC11068576 PMID: 38702733
Selvarajan, I., M. Kiema, R-T. Huang, J. Li, J. Zhu, P. Pölönen, T. Örd, K. Õunap, M. Godiwala, A. Kathryn Golebiewski, et al., "Coronary Artery Disease Risk Variant Dampens the Expression of CALCRL by Reducing HSF Binding to Shear Stress Responsive Enhancer in Endothelial Cells In Vitro.", Arterioscler Thromb Vasc Biol, vol. 44, issue 6, pp. 1330-1345, 2024 Jun.
PMCID: PMC11111333 PMID: 38602103
Li, J., J. Zhu, O. Gray, D. R. Sobreira, D. Wu, R-T. Huang, B. Miao, N. J. Sakabe, M. D. Krause, M. U. Kaikkonen, et al., "Mechanosensitive super-enhancers regulate genes linked to atherosclerosis in endothelial cells.", J Cell Biol, vol. 223, issue 3, 2024 Mar 04.
PMCID: PMC10794123 PMID: 38231044
Shin, J., J. Hong, J. Edwards-Glenn, I. Krukovets, S. Tkachenko, M. L. Adelus, C. E. Romanoski, S. Rajagopalan, E. Podrez, T. V. Byzova, et al., "Unraveling the Role of Sex in Endothelial Cell Dysfunction: Evidence From Lineage Tracing Mice and Cultured Cells.", Arterioscler Thromb Vasc Biol, vol. 44, issue 1, pp. 238-253, 2024 Jan.
PMCID: PMC10842863 PMID: 38031841
Larrinaga, T. M., G. P. Farman, R. M. Mayfield, M. Yuen, R. C. Ahrens-Nicklas, S. T. Cooper, C. T. Pappas, and C. C. Gregorio, "Lmod2 is necessary for effective skeletal muscle contraction.", Sci Adv, vol. 10, issue 11, pp. eadk1890, 2024 Mar 15.
PMCID: PMC10936868 PMID: 38478604
Ryniawec, J. M., A. Amoiroglou, and G. C. Rogers, "Generating CRISPR-edited clonal lines of cultured S2 cells.", Biol Methods Protoc, vol. 9, issue 1, pp. bpae059, 2024.
PMCID: PMC11357795 PMID: 39206452
Adelus, M. L., J. Ding, B. T. Tran, A. C. Conklin, A. K. Golebiewski, L. K. Stolze, M. B. Whalen, D. A. Cusanovich, and C. E. Romanoski, "Single cell 'omic profiles of human aortic endothelial cells and human atherosclerotic lesions reveals heterogeneity of endothelial subtype and response to activating perturbations.", bioRxiv, 2024 Jan 17.
PMCID: PMC10104082 PMID: 37066416
Iwanski, J. B., C. T. Pappas, R. M. Mayfield, G. P. Farman, R. Ahrens-Nicklas, J. M. Churko*, and C. C. Gregorio*, "Leiomodin 2 neonatal dilated cardiomyopathy mutation results in altered actin gene signatures and cardiomyocyte dysfunction.", NPJ Regen Med, vol. 9, issue 1, pp. 21 , 2024 Sep 16.
PMCID: PMC11405699 PMID: 39285234
Xing, Y., M. Sin- Man Tsang, Z. Yang, M. Haitian Wang, V. Pivniouk, A. Sze- Yin Leung, T-F. Leung, M. Roponen, B. Schaub, D. Vercelli, et al., "Immune modulation by rural exposures and allergy protection.", Pediatr Allergy Immunol, vol. 35, issue 2, pp. e14086, 2024 Feb.
PMID: 38351891
Michael, A. N., O. Pivniouk, P. C. Ezeh, S. Banskar, S. Hahn, A. DeVries, K. O'Connell, V. Pivniouk, and D. Vercelli, "Administration of a Bacterial Lysate to the Airway Compartment Is Sufficient to Inhibit Allergen-Induced Lung Eosinophilia in Germ-free Mice.", J Leukoc Biol, 2024 Mar 12.
PMID: 38470858
Morrison, C., E. Weterings, N. Gravbrot, M. Hammer, M. Weinand, A. Sanan, R. Pandey, D. Mahadevan, and B. Stea, "Gene Expression Patterns Associated with Survival in Glioblastoma.", Int J Mol Sci, vol. 25, issue 7, 2024 Mar 25.
PMCID: PMC11011684 PMID: 38612480
Lou, E., J. Xiu, Y. Baca, A. Saeed, A. Prakash, S. Gholami, S. Subramanian, T. K. Starr, E. Fontana, R. Pandey, et al., "Differential landscape of immune evasion in oncogenic RAS-driven primary and metastatic colorectal cancers.", Mol Ther Oncol, vol. 32, issue 1, pp. 200786, 2024 Mar 21.
PMCID: PMC10963927 PMID: 38596288
Li, N. C., N. Iannuzo, S. A. Christenson, P. R. Langlais, M. Kraft, J. G. Ledford, and X. Li, "Investigation of lactotransferrin messenger RNA expression levels as an anti-type 2 asthma biomarker.", J Allergy Clin Immunol, 2024 May 24.
PMID: 38797239
Quintela-Fandino, M., B. Bermejo, E. Zamora, F. Moreno, J. Ángel Garcia-Saenz, S. Pernas, N. Martinez Jañez, D. Jiménez, E. Adrover, R. Andrés, et al., "High mechanical conditioning by tumor extracellular matrix stiffness is a predictive biomarker for anti-fibrotic therapy in HER2-negative breast cancer.", Clin Cancer Res, 2024 Sep 16.
PMID: 39283720
Simpson, C. E., J. G. Ledford, and G. Liu, "Application of Metabolomics across the Spectrum of Pulmonary and Critical Care Medicine.", Am J Respir Cell Mol Biol, vol. 71, issue 1, pp. 1-9, 2024 Jul.
PMCID: PMC11225873 PMID: 38547373
2023
Pederson, W. P., L. M. Ellerman, Y. Jin, H. Gu, and J. G. Ledford, "Metabolomic Profiling in Mouse Model of Menopause-Associated Asthma.", Metabolites, vol. 13, issue 4, 2023 Apr 11.
PMCID: PMC10145474 PMID: 37110204
Voraphani, N., D. A. Stern, J. G. Ledford, A. L. Spangenberg, J. Zhai, A. L. Wright, W. J. Morgan, M. Kraft, D. L. Sherrill, J. A. Curtin, et al., "Circulating CC16 and Asthma: A Population-Based, Multi-Cohort Study from Early Childhood Through Adult Life.", Am J Respir Crit Care Med, 2023 Jul 31.
PMID: 37523710
Iannuzo, N., A. Blythe C. Dy, S. Guerra, P. R. Langlais, and J. G. Ledford, "The Impact of CC16 on Pulmonary Epithelial-Driven Host Responses during Infection in Mouse Tracheal Epithelial Cells.", Cells, vol. 12, issue 15, 2023 Aug 01.
PMCID: PMC10416898 PMID: 37566063
Vercelli, D., and S. V. Lynch, "Interactions Between Host Epigenetics and Microbiota: Who Does What to Whom, When and Why?", J Allergy Clin Immunol, 2023 Jan.
PMID: 36720286
Tanyaratsrisakul, S., A. Blythe C. Dy, F. Polverino, M. Numata, and J. G. Ledford, "Myeloid-associated differentiation marker is associated with type 2 asthma and is upregulated by human rhinovirus infection.", Front Immunol, vol. 14, pp. 1237683, 2023.
PMCID: PMC10450947 PMID: 37638015