Cusanovich Lab Develops New Single-Cell Epigenomic Assay and Surveys Gene Regulation Across Human Tissues in Science

Release Date: 
Nov 12, 2020

Work from Research Assistant Professor Darren Cusanovich, PhD's Laboratory in collaboration with his former colleagues at the University of Washington developed a new single-cell chromatin assay that can generate data on 100s of thousands or millions of cells at a time. The group then used this method to profile how the genome regulates gene expression across various tissues of the human body. This represents one of the largest single-cell chromatin datasets ever published and suggests many novel aspects of human biology, including cataloging regulatory elements across 17% of the genome, identifying a novel regulator of neuronal development and helping to highlight the adrenal gland as a normal site of red blood cell production in development. Read more here.