Cardiovascular Biology and Disease

Diseases of the cardiovascular system are the leading cause of death and morbidity in the US.  CMM faculty with interests in cardiovascular biology use a wide variety of interdisciplinary approaches to investigate the molecular mechanisms of heart development, heart function, heart disease, and other malfunctions of the cardiovascular system. Particular strengths are in the areas of cardiovascular development, mechanisms of myofibril assembly and function, and cardiomyopathy. 

Cardiovascular research faculty in CMM are members of the Sarver Heart Center’s Molecular Cardiovascular Research Program (MCRP). In concert with MCRP faculty from other Departments, the CMM cardiovascular group provides a strong training environment for undergraduates, medical students, graduate students, postdocs and medical residents.

Primary Faculty
Associate Vice President for Research, Division of Agriculture, Life and Veterinary Sciences, and Cooperative Extension
Associate Dean, Research-Agriculture and Life Sciences
Professor, Cellular and Molecular Medicine
Professor, Molecular and Cellular Biology
Professor, BIO5 Institute
(520) 621-7201

Investigating the mechanisms regulating lineage diversification and morphogenesis during embryogenesis.
Assistant Professor, Cellular and Molecular Medicine
Assistant Professor, Genetics GIDP
Assistant Professor, Physiological Sciences GIDP
Assistant Professor, Biomedical Engineering
Director, iPS Cell Core
(520) 626-2347

Using informatics to understand cardiovascular development and disease mechanisms using human induced pluripotent stem cells.
Assistant Professor, Cellular and Molecular Medicine
Assistant Professor, Physiological Sciences GIDP
Assistant Professor, Biomedical Engineering
Assistant Professor, BIO5 Institute
Assistant Professor, Clinical Translational Sciences
(520) 621-1950

Deciphering the structural basis for cardiac muscle contraction at the molecular level in healthy heart physiology and disease.
Professor, Cellular and Molecular Medicine
Professor, BIO5 Institute
Professor, Cancer Biology GIDP
Professor, Genetics GIDP
(520) 626-4901

Exploring the synergistic activities of TGFbeta deficiency and the gut microbiome in colon cancer.
Professor, Cellular and Molecular Medicine
Professor, Physiology
Professor, Molecular and Cellular Biology
Professor, BIO5 Insitutue
Professor, Physiological Sciences GIDP
Professor, Biomedical Engineering
(520) 626-3641

Discovering mechanisms whereby the giant filamentous protein titin influence muscle structure and function.
Vice Dean for Innovation and Development – COM - Tucson
Department Head, Cellular and Molecular Medicine
Co-Director, Sarver Heart Center
Director, Molecular Cardiovascular Research Program
Professor, Cellular and Molecular Medicine
Professor, Molecular and Cellular Biology
Professor, BIO5 Institute
(520) 626-8113

Identifying the components and molecular mechanisms regulating cytoskeletal architecture in cardiac and skeletal muscle during normal development and in disease.
Professor, Cellular and Molecular Medicine
Professor, Physiological Sciences GIDP
Professor, BIO5 Institute
Professor, Biomedical Engineering
Co-Chair, Arizona Biological and Biomedical Program
(520) 621-0291

Exploring cardiac muscle mechanics, the regulation of myocardial contraction, the molecular basis of inherited cardiomyopathies, and myofilament proteins.
Retired Professor, Cellular and Molecular Medicine
(520) 626-9370

Understanding the cellular and molecular mechanisms underlying organ development in the vertebrate embryo.
Associate Professor, Cellular and Molecular Medicine - (Research Scholar Track)
(520) 626-4198

Focusing on the role of titin-based mechanosensing in diaphragm physiology.
Research Assistant Professor, Cellular and Molecular Medicine
(520) 626-5209

My work is focused on understanding how the architecture of muscle cells is regulated, with particular emphasis on how actin filaments assemble and how aberrant actin filament assembly leads to myopathies.
Professor, Cellular and Molecular Medicine
Research Scientist, Sarver Heart Center
Investigator, Center for Toxicology
Professor, Physiological Sciences GIDP
(520) 626-2326

Research in this lab is focused on 3 projects. A. Regulation of epithelial-mesenchymal transition in heart development and cancer. B. Mitochondrial transfer from stem cells to myocytes. C. Congenital heart disease from exposure to trichloroethylene.
Affiliated Faculty
Professor, Biomedical Engineering
Professor, Medicine
Professor, Cellular and Molecular Medicine
Professor, Physiological Sciences GIDP
Professor, BIO5 Institute
(520) 626-8001

My lab studies the relationship between sarcomeric structure and dynamics in the development of complex genetic cardiomyopathies.