Cancer Cell Biology

Cancer Biology focuses on fundamental mechanisms in cancer development and progression with the long-term aim of promoting the translation of novel therapies.

Cancer Biology research covers a broad spectrum of inquiry into the mechanisms of cancer progression, including genomic and mRNA regulation, signal transduction, intracellular trafficking, cell polarity, metastasis and basic mechanisms of growth, invasion and survival. Investigators begin by utilizing a variety of tools to ask basic science questions about the initiation and progression of cancer (including model organisms and high-throughput techniques) and continue on through the pre-clinical application of these discoveries using mouse-modeling.

Primary Faculty
Associate Vice President for Research, Division of Agriculture, Life and Veterinary Sciences, and Cooperative Extension
Associate Dean, Research-Agriculture and Life Sciences
Professor, Cellular and Molecular Medicine
Professor, Molecular and Cellular Biology
Professor, BIO5 Institute
(520) 621-7201

Investigating the mechanisms regulating lineage diversification and morphogenesis during embryogenesis.
Deputy Dean, Research Affairs
Professor, Cellular and Molecular Medicine
Professor, Radiation Oncology
Professor, Molecular and Cellular Biology
Professor, Applied Biosciences GIDP
Professor, Cancer Biology GIDP
(520) 626-7553

Studying the molecular mechanisms of human cancer progression and metastasis and the regulation of cell surface adhesion molecules, called integrins.
Professor, Cellular and Molecular Medicine
Professor, BIO5 Institute
Professor, Cancer Biology GIDP
Professor, Genetics GIDP
(520) 626-4901

Exploring the synergistic activities of TGFbeta deficiency and the gut microbiome in colon cancer.
Director of Graduate Studies, Genetics GIDP
Associate Professor, Cellular and Molecular Medicine
Scientific Director, Cancer Biology Research Program
Associate Professor, Cancer Biology GIDP
(520) 626-7979

Analyzing genomic instability in cancer susceptibility.
Vice Dean for Innovation and Development – COM - Tucson
Department Head, Cellular and Molecular Medicine
Co-Director, Sarver Heart Center
Director, Molecular Cardiovascular Research Program
Professor, Cellular and Molecular Medicine
Professor, Molecular and Cellular Biology
Professor, BIO5 Institute
(520) 626-8113

Identifying the components and molecular mechanisms regulating cytoskeletal architecture in cardiac and skeletal muscle during normal development and in disease.
Associate Professor, Cellular and Molecular Medicine (Research Scholar Track)
Associate Professor, Cancer Biology GIDP
(520) 626-8044

Exploring the role and regulation of serine protease Kallikrein 6 in metastatic colon cancer.
Associate Professor, Cellular and Molecular Medicine
Associate Professor, Genetics GIDP
Associate Professor, Cancer Biology GIDP
(520) 626-9545

Exploring the connection between epigenetic instability and chromosome damage.
Professor, Cellular and Molecular Medicine
Program Leader, Prostate Cancer Research
Co-Program Leader, Cancer Biology Research Program
Professor, BIO5 Institute
(520) 626-2269

Defining the mechanisms by which cell adhesion and the tumor microenvironment promote prostate cancer progression and metastasis.
Assistant Professor, Cellular and Molecular Medicine
Assistant Professor, Cancer Biology GIDP
(520) 626-4616

Understanding How Cytoskeletal Architecture Regulates Cancer Metastasis
Research Assistant Professor, Cellular and Molecular Medicine
Coordinator, Biomedical Informatics
(520) 626-0391

Investigating the underlying molecular profiles in cancer patient data using integrated computational analysis of multi-omics data in the context of disease outcome, treatment and progression.
Associate Professor, Cellular and Molecular Medicine
Associate Department Head, Faculty Development, Cellular and Molecular Medicine
Associate Professor, Molecular and Cellular Biology
Associate Professor, BIO5 Institute
Associate Professor, Cancer Biology GIDP
Associate Professor, Genetics GIDP
(520) 626-3925

Understanding cellular mechanisms that regulate centrosome duplication, nuclear organization, and genomic integrity.
Professor, Cellular and Molecular Medicine
Research Scientist, Sarver Heart Center
Investigator, Center for Toxicology
Professor, Physiological Sciences GIDP
(520) 626-2326

Research in this lab is focused on 3 projects. A. Regulation of epithelial-mesenchymal transition in heart development and cancer. B. Mitochondrial transfer from stem cells to myocytes. C. Congenital heart disease from exposure to trichloroethylene.
Research Assistant Professor, Cellular and Molecular Medicine
(520) 626-9048

Advancing knowledge on cancers including their biology, signal transduction and novel therapeutics.
Interim Director, Cancer Center Division
Professor, Cellular and Molecular Medicine
Professor, Radiation Oncology
Associate Director, Basic Sciences, University of Arizona Cancer Center
(520) 626-2548

Discovering mechanistic insights into the roles of aberrant DNA repair in the development of cancer, autoimmunity, and other diseases.
Assistant Professor, Cellular and Molecular Medicine
Assistant Professor, BIO5 Institute
Member, University of Arizona Cancer Center
Member, Steele Children's Research Center
(520) 626-0395

Combining chemical biology and computer vision approaches to discover cellular communication mechanisms controlling cell fate, self-organization and disease progression of regenerative tissues
Assistant Professor, Cellular and Molecular Medicine
(520) 626-7756

Understanding the complex biological mechanisms that allow cancer cells to thrive in the hypoxic tumor microenvironment and developing new therapeutic strategies to oppose hypoxia-mediated therapeutic resistance.
Professor, Cellular and Molecular Medicine
Professor, BIO5 Institute
Director, Willed Body Program
(520) 626-2557

The Wilson laboratory works on the establishment and maintenance of the integrity of the intestine through the regulation of membrane trafficking to the apical plasma membrane domain.
Professor, Cellular and Molecular Medicine
Associate Head for Research

Investigation of in vivo and in vitro Organoid Models of Gastrointestinal Diseases
Affiliated Faculty
Professor, Surgery
Associate Professor, Pathology
Associate Professor, Cellular and Molecular Medicine
Professor, Ophthalmology
Professor, Cancer Biology GIDP
(520) 626-1913