Complex Diseases - Biology and Genetics

Human complex diseases (e.g., asthma, cancer, cardiovascular and metabolic disorders, neuro-degenerative and neuro-developmental diseases) are major biomedical challenges, because they are common but difficult to decipher. The complexity of these diseases likely reflects intricate interactions among genetic, environmental and developmental factors that modify disease susceptibility and severity.

Understanding complex diseases is urgent, because these conditions impose a burden on society. Yet, this goal cannot be achieved by isolated research disciplines. Rather, it requires a novel paradigm that successfully integrates research across multiple fields. Because an interdisciplinary approach to basic and translational research is perfectly aligned with the mission of the Department of Cellular and Molecular Medicine, the Department chose complex diseases as one of its focus areas. Research targets the developmental and evolutionary biology, immunology, epigenetics, genetics and functional genomics of complex diseases using human and animal models. Our groups seek to identify the mechanistic architecture of complex diseases by focusing on the biological components that are shared by seemingly distinct diseases (for instance, asthma, neurodegenerative and cardiovascular diseases). The Department also sponsors an annual graduate colloquium (Problems in Complex Disease Biology, CMM595H) that has become a nationally renowned forum for complex disease-related themes. Our overall goal is to foster the emergence of a new conceptual, experimental and training paradigm in complex disease biology.

Professor, Cellular and Molecular Medicine
Associate Vice President for Research, Agriculture - Life and Veterinary Sciences, Cooperative Extension
Associate Dean for Research, College of Agriculture and Life Sciences
Professor, BIO5 Institute
Professor, Molecular and Cellular Biology
(520) 661-6382

Lineage diversification and morphogenesis during embryogenesis.
Assistant Professor, Cellular and Molecular Medicine
(520) 626-8639

Developing new single-cell genomic technologies and applying those technologies to animal models and primary samples to better understand the gene regulatory basis of development and disease.
Professor and Department Head, Cellular and Molecular Medicine
Interim Director, Sarver Heart Center
Director, Molecular Cardiovascular Research Program
Assistant Vice Provost, Global Health Sciences
Director, UArizona Health Sciences Global and Online
Czarina M. and Humberto S. Lopez Endowed Chair for Excellence in Cardiovascular Research
American Association for the Advancement of Science (AAAS) Fellow
Professor, BIO5 Institute
Professor, Molecular and Cellular Biology
(520) 626-8113

Identifying the components and molecular mechanisms regulating cytoskeletal architecture in cardiac and skeletal muscle during normal development and in disease.
Associate Professor, Cellular and Molecular Medicine
Co-Director, Clinical Translational Sciences Graduate Program
Associate Director of Translational Research, Asthma & Airways Disease Research Center
Associate Professor, Immunobiology
520-626-0276

Determining mechanisms by which endogenous lung proteins mediate various states of lung inflammation, pathogen infection and lung disease progression.
Associate Professor, Cellular and Molecular Medicine - (Research Scholar Track) (Career Track)
Assistant Research Scientist, Respiratory Sciences
(520) 626-9644

Studying the molecular mechanisms of allergy and asthma using mouse models.
Associate Professor, Cellular and Molecular Medicine
Associate Professor, Clinical Translational Sciences
Associate Professor, Genetics GIDP
Associate Professor, Asthma and Airway Disease Research Center
Associate Professor, Cancer Biology GIDP
Member, BIO5 Institute
(520) 626-7244

Systems genetics approaches to identify mechanisms of complex disease.
Professor, Cellular and Molecular Medicine
Director, Cancer Center
Professor, Cancer Biology GIDP
Professor, Chemistry and Biochemistry
Professor, Genetics GIDP
Professor, Radiation Oncology
(520) 626-5549

Discovering mechanistic insights into the roles of aberrant DNA repair in the development of cancer, autoimmunity, and other diseases.
Assistant Professor, Cellular and Molecular Medicine
Co-Director, Graduate Program in Molecular Medicine
Assistant Professor, BIO5 Institute
(520) 626-0395

Combining chemical biology and computer vision approaches to discover cellular communication mechanisms controlling cell fate, self-organization and disease progression of regenerative tissues
Regents Professor, Cellular and Molecular Medicine
Director, Arizona Center for the Biology of Complex Diseases
Associate Director, Asthma and Airway Disease Research Center
Professor, BIO5 Institute
Professor, Genetics GIDP
(520) 626-6387

Genetic, epigenetic and environmental mechanisms that control susceptibility to complex lung diseases
Professor, Cellular and Molecular Medicine
Associate Head, Research
Professor, Cancer Biology GIDP
(520) 626-4342

Investigation of in vivo and in vitro Organoid Models of Gastrointestinal Diseases