Cell Polarity and Intracellular Trafficking

Formation and maintenance of cellular polarity requires the action of polarity complexes, signaling molecules, cytoskeletal elements, and the regulated trafficking of proteins to specific membrane domains. Our groups study the intricate networks that regulate polarity and intracellular trafficking in a variety of systems including epithelial cells, neurons, and cells of the immune system. In epithelial cells, loss of polarity can result in kidney disease, inflammatory bowel disease, and lung disease. Neurons require polarity to establish and maintain connections between the neural circuits. Effective immunity requires proper trafficking of important effector molecules, and these pathways are often disrupted by pathogens to evade the immune response. Importantly, these diverse cell types use similar machineries to establish and maintain polarity, as well as to mediate intracellular trafficking of membrane proteins.

Associate Vice President for Research, Division of Agriculture, Life and Veterinary Sciences, and Cooperative Extension
Associate Dean for Research, College of Agriculture and Life Sciences
Professor, Cellular and Molecular Medicine
Professor, Molecular and Cellular Biology
Professor, BIO5 Institute
(520) 661-6382

Lineage diversification and morphogenesis during embryogenesis.
Associate Professor, Cellular and Molecular Medicine
Associate Professor, Immunobiology
Associate Professor, BIO5 Institute
(520) 626-1044

Exploring the regulation and function of key cell surface receptors in cells of the immune system.
Professor, Cellular and Molecular Medicine
Professor, BIO5 Institute
Director, Willed Body Program
(520) 626-2557

The Wilson laboratory works on the establishment and maintenance of the integrity of the intestine through the regulation of membrane trafficking to the apical plasma membrane domain.