Mouneimne Lab finds breast cancer's response to tumor stiffness may predict bone metastasis

Release Date: 
Aug 24, 2021

Adam Watson, Gus Mouneimne, and a cadre of stellar collaborators in CMM and beyond, demonstrate that the stiffness of the tumor microenvironment can persistently alter cancer cell behavior, even after dissemination to softer microenvironments, by a process termed “mechanical memory.” Mechanical conditioning by stiff microenvironments promotes invasion and osteolysis, and this study develops a mechanical conditioning (MeCo) score associated with bone metastasis in patients.

Read more:

https://healthsciences.arizona.edu/newsroom/news-releases/2021/study-finds-breast-cancers-response-tumor-stiffness-may-predict-bone

https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00664-1