Mouneimne Lab Finds Breast Cancer's Response to Tumor Stiffness May Predict Bone Metastasis

Release Date: 
Aug 24, 2021

Adam Watson, Gus Mouneimne, and a cadre of stellar collaborators in CMM and beyond, demonstrate that the stiffness of the tumor microenvironment can persistently alter cancer cell behavior, even after dissemination to softer microenvironments, by a process termed “mechanical memory.” Mechanical conditioning by stiff microenvironments promotes invasion and osteolysis, and this study develops a mechanical conditioning (MeCo) score associated with bone metastasis in patients.

Read more: