Anne Cress, PhD

Senior Associate Dean
Professor, Cellular and Molecular Medicine
Professor, Radiation Oncology
Professor, Molecular and Cellular Biology
Professor, Applied Biosciences GIDP
Professor, Cancer Biology GIDP
Research Interests: 

My research is to understand the molecular mechanisms of cell adhesion and human tumor metastasis. We discovered cell adhesion adaptive responses of tumors dependent upon adhesion receptors called integrins. The adaptive responses are essential for normal tissue development but are used for nepharious purposes in cancer. We use tools of biochemistry, cell biology and genetics.

Molecular Medicine Grad Program: 
Yes

Bibliography

2021

Casillas, A. L., S. S. Chauhan, R. K. Toth, A. G. Sainz, A. N. Clements, C. C. Jensen, P. R. Langlais, C. K. Miranti, A. E. Cress, and N. A. Warfel, "Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors.", Oncogene, 2021 Jul 02. PMID: 34211090
Quijada, H., T. Bermudez, C. L. Kempf, D. G. Valera, A. N. Garcia, S. M. Camp, J. H. Song, E. Franco, J. K. Burt, B. Sun, et al., "Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody.", Eur Respir J, vol. 57, issue 5, 2021 05. PMCID: PMC8100338  PMID: 33243842
Harryman, W. L., K. D. Marr, D. Hernandez-Cortes, R. B. Nagle, J. G. N. Garcia, and A. E. Cress, "Cohesive cancer invasion of the biophysical barrier of smooth muscle.", Cancer Metastasis Rev, vol. 40, issue 1, pp. 205-219, 2021 Mar. PMCID: PMC8189031  PMID: 33398621

2020

Johnson, M. D., U. S. Younis, S. V. Menghani, K. J. Addison, M. Whalen, A. L. Pilon, A. E. Cress, F. Polverino, C. Romanoski, M. Kraft, et al., "CC16 Binding to α4β1 Integrin (VLA-4) Protects Against Infection.", Am J Respir Crit Care Med, 2020 Dec 16. PMID: 33326355
Kelly, G. T., R. Faraj, Z. Dai, A. E. Cress, and T. Wang, "A mutation found in esophageal cancer alters integrin β4 mRNA splicing.", Biochem Biophys Res Commun, vol. 529, issue 3, pp. 726-732, 2020 08 27. PMID: 32736699
Sun, B. L., X. Sun, N. Casanova, A. N. Garcia, R. Oita, A. M. Algotar, S. M. Camp, V. Reyes Hernon, T. Gregory, A. E. Cress, et al., "Role of secreted extracellular nicotinamide phosphoribosyltransferase (eNAMPT) in prostate cancer progression: Novel biomarker and therapeutic target.", EBioMedicine, vol. 61, pp. 103059, 2020 Nov. PMCID: PMC7559260  PMID: 33045468

2019

Wang, M., J. P. Hinton, J. M. C. Gard, J. G. N. Garcia, B. S. Knudsen, R. B. Nagle, and A. E. Cress, "Integrin α6β4E variant is associated with actin and CD9 structures and modifies the biophysical properties of cell-cell and cell-extracellular matrix interactions.", Mol Biol Cell, vol. 30, issue 7, pp. 838-850, 2019 03 21. PMCID: PMC6589785  PMID: 30865564
Harryman, W. L., N. A. Warfel, R. B. Nagle, and A. E. Cress, "The Tumor Microenvironments of Lethal Prostate Cancer.", Adv Exp Med Biol, vol. 1210, pp. 149-170, 2019 01 01. PMID: 31900909
Wang, M., B. S. Knudsen, R. B. Nagle, G. C. Rogers, and A. E. Cress, "A method of quantifying centrosomes at the single-cell level in human normal and cancer tissue.", Mol Biol Cell, vol. 30, issue 7, pp. 811-819, 2019 03 21. PMID: 30699045
Wang, M., R. B. Nagle, B. S. Knudsen, A. E. Cress, and G. C. Rogers, "Centrosome loss results in an unstable genome and malignant prostate tumors.", Oncogene, 2019 09 02. PMID: 31477840
Rubenstein, C. S., J. M. C. Gard, M. Wang, J. E. McGrath, N. Ingabire, J. P. Hinton, K. D. Marr, S. J. Simpson, R. B. Nagle, C. K. Miranti, et al., "Gene editing of α6 integrin inhibits muscle invasive networks and increases cell-cell biophysical properties in prostate cancer.", Cancer Res, 07/2019. PMID: 31337652

2018

Saylor, J., Z. Ma, H. S. Goodridge, F. Huang, A. E. Cress, S. J. Pandol, S. L. Shiao, A. C. Vidal, L. Wu, N. G. Nickols, et al., "Spatial Mapping of Myeloid Cells and Macrophages by Multiplexed Tissue Staining.", Front Immunol, vol. 9, pp. 2925, 2018. PMCID: PMC6302234  PMID: 30619287
Das, L., J. M. C. Gard, R. Prekeris, R. B. Nagle, C. Morrissey, B. S. Knudsen, C. K. Miranti, and A. E. Cress, "Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer.", Mol Cancer Res, vol. 16, issue 8, pp. 1319-1331, 2018 08. PMCID: PMC6369592  PMID: 29759989
Pollan, S. G., F. Huang, J. M. Sperger, J. M. Lang, C. Morrissey, A. E. Cress, C. Y. Chu, N. A. Bhowmick, S. You, M. R. Freeman, et al., "Regulation of inside-out β1-integrin activation by CDCP1.", Oncogene, vol. 37, issue 21, pp. 2817-2836, 2018 05. PMID: 29511352

2017

Harryman, W. L., J. M. C. Gard, K. W. Pond, S. J. Simpson, L. H. Heppner, D. Hernandez-Cortes, A. S. Little, J. M. Eschbacher, and A. E. Cress, "Targeting the Cohesive Cluster Phenotype in Chordoma via β1 Integrin Increases Ionizing Radiation Efficacy.", Neoplasia, vol. 19, issue 11, pp. 919-927, 2017 Nov. PMCID: PMC5614733  PMID: 28954241
Das, L., T. A. Anderson, J. M. C. Gard, I. C. Sroka, S. R. Strautman, R. B. Nagle, C. Morrissey, B. S. Knudsen, and A. E. Cress, "Characterization of Laminin Binding Integrin Internalization in Prostate Cancer Cells.", J Cell Biochem, vol. 118, issue 5, pp. 1038-1049, 2017 05. PMCID: PMC5553695  PMID: 27509031
Wang, M., R. B. Nagle, B. S. Knudsen, G. C. Rogers, and A. E. Cress, "A basal cell defect promotes budding of prostatic intraepithelial neoplasia.", J Cell Sci, 2017 01. PMCID: PMC5394777  PMID: 27609833

2016

Song, S., K. N. Jacobson, K. M. McDermott, S. P. Reddy, A. E. Cress, H. Tang, S. M. Dudek, S. M. Black, J. G. N. Garcia, A. Makino, et al., "ATP promotes cell survival via regulation of cytosolic [Ca2+] and Bcl-2/Bax ratio in lung cancer cells.", Am J Physiol Cell Physiol, vol. 310, issue 2, pp. C99-114, 2016 Jan 15. PMCID: PMC4719033  PMID: 26491047
Sroka, I. C., H. Chopra, L. Das, J. M. C. Gard, R. B. Nagle, and A. E. Cress, "Schwann Cells Increase Prostate and Pancreatic Tumor Cell Invasion Using Laminin Binding A6 Integrin.", J Cell Biochem, vol. 117, issue 2, pp. 491-9, 2016 Feb. PMCID: PMC4809241  PMID: 26239765
Sroka, I. C., H. Chopra, L. Das, J. M. C. Gard, R. B. Nagle, and A. E. Cress, "Schwann Cells Increase Prostate and Pancreatic Tumor Cell Invasion Using Laminin Binding A6 Integrin.", J Cell Biochem, vol. 117, issue 2, pp. 491-9, 2016 Feb. PMCID: PMC4809241  PMID: 26239765
Harryman, W. L., J. P. Hinton, C. P. Rubenstein, P. Singh, R. B. Nagle, S. J. Parker, B. S. Knudsen, and A. E. Cress, "The Cohesive Metastasis Phenotype in Human Prostate Cancer.", Biochim Biophys Acta, vol. 1866, issue 2, pp. 221-231, 2016 12. PMCID: PMC5534328  PMID: 27678419
WL, H., and P. E, Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers. Am J Transl Res 2016;8(2):940-954., 2016.
Harryman, W. L., E. Pond, P. Singh, A. S. Little, J. M. Eschbacher, R. B. Nagle, and A. E. Cress, "Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers.", Am J Transl Res, vol. 8, issue 2, pp. 940-54, 2016. PMCID: PMC4846938  PMID: 27158381

2015

Chen, W., Y. Epshtein, X. Ni, R. O. Dull, A. E. Cress, J. G. N. Garcia, and J. R. Jacobson, "Role of Integrin β4 in Lung Endothelial Cell Inflammatory Responses to Mechanical Stress.", Sci Rep, vol. 5, pp. 16529, 2015. PMCID: PMC4647208  PMID: 26572585
Geffre, C. P., E. Pond, G. D. Pond, I. C. Sroka, J. M. Gard, B. A. Skovan, W. E. Meek, T. H. Landowski, R. B. Nagle, and A. E. Cress, "Combined micro CT and histopathology for evaluation of skeletal metastasis in live animals.", Am J Transl Res, vol. 7, issue 2, pp. 348-55, 2015. PMCID: PMC4399097  PMID: 25901201
Geffre, C. P., E. Pond, G. D. Pond, I. C. Sroka, J. M. Gard, B. A. Skovan, W. E. Meek, T. H. Landowski, R. B. Nagle, and A. E. Cress, "Combined micro CT and histopathology for evaluation of skeletal metastasis in live animals.", Am J Transl Res, vol. 7, issue 2, pp. 348-55, 2015. PMCID: PMC4399097  PMID: 25901201
Fu, P., P. V. Usatyuk, J. Jacobson, A. E. Cress, J. G. N. Garcia, R. Salgia, and V. Natarajan, "Role played by paxillin and paxillin tyrosine phosphorylation in hepatocyte growth factor/sphingosine-1-phosphate-mediated reactive oxygen species generation, lamellipodia formation, and endothelial barrier function.", Pulm Circ, vol. 5, issue 4, pp. 619-30, 2015 Dec. PMCID: PMC4671736  PMID: 26697169
Qian, Z., T. Zhou, C. I. Gurguis, X. Xu, Q. Wen, J. Lv, F. Fang, L. Hecker, A. E. Cress, V. Natarajan, et al., "Nuclear factor, erythroid 2-like 2-associated molecular signature predicts lung cancer survival.", Sci Rep, vol. 5, pp. 16889, 2015 Nov 24. PMCID: PMC4657037  PMID: 26596768
Chen, W., Y. Epshtein, X. Ni, R. O. Dull, A. E. Cress, J. G. N. Garcia, and J. R. Jacobson, "Role of Integrin β4 in Lung Endothelial Cell Inflammatory Responses to Mechanical Stress.", Sci Rep, vol. 5, pp. 16529, 2015 Nov 17. PMCID: PMC4647208  PMID: 26572585

2014

Landowski, T. H., J. Gard, E. Pond, G. D. Pond, R. B. Nagle, C. P. Geffre, and A. E. Cress, "Targeting integrin α6 stimulates curative-type bone metastasis lesions in a xenograft model.", Mol Cancer Ther, vol. 13, issue 6, pp. 1558-66, 2014 Jun. PMCID: PMC4069206  PMID: 24739392