Carol C. Gregorio, PhD

Professor and Department Head, Cellular and Molecular Medicine
Interim Director, Sarver Heart Center
Director, Molecular Cardiovascular Research Program
Assistant Vice Provost, Global Health Sciences
Director, UArizona Health Sciences Global and Online
Czarina M. and Humberto S. Lopez Endowed Chair for Excellence in Cardiovascular Research
American Association for the Advancement of Science (AAAS) Fellow
Professor, BIO5 Institute
Professor, Molecular and Cellular Biology
Molecular Medicine Grad Program: 
Yes

Bibliography

2021

Colpan, M., J. Iwanski, and C. C. Gregorio, "CAP2 is a regulator of actin pointed end dynamics and myofibrillogenesis in cardiac muscle.", Commun Biol, vol. 4, issue 1, pp. 365, 2021 Mar 19. PMCID: PMC7979805  PMID: 33742108
Iwanski, J., S. G. Kazmouz, S. Li, B. Stansfield, T. T. Salem, S. Perez-Miller, T. Kazui, L. Jena, J. L. Uhrlaub, S. Lick, et al., "Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells.", Stem Cell Reports, 2021 Sep 01. PMCID: PMC8407952  PMID: 34525378

2020

Mi-Mi, L., G. P. Farman, R. M. Mayfield, J. Strom, M. Chu, C. T. Pappas, and C. C. Gregorio, "In vivo elongation of thin filaments results in heart failure.", PLoS One, vol. 15, issue 1, pp. e0226138, 2020. PMCID: PMC6941805  PMID: 31899774
Tolkatchev, D., G. E. Smith, L. E. Schultz, M. Colpan, G. L. Helms, J. R. Cort, C. C. Gregorio, and A. S. Kostyukova, "Leiomodin creates a leaky cap at the pointed end of actin-thin filaments.", PLoS Biol, vol. 18, issue 9, pp. e3000848, 2020 09. PMCID: PMC7500696  PMID: 32898131

2019

Ahrens-Nicklas, R. C., C. T. Pappas, G. P. Farman, R. M. Mayfield, T. M. Larrinaga, L. Medne, A. Ritter, I. D. Krantz, C. Murali, K. Y. Lin, et al., "Disruption of cardiac thin filament assembly arising from a mutation in : A novel mechanism of neonatal dilated cardiomyopathy.", Sci Adv, vol. 5, issue 9, pp. eaax2066, 2019 09. PMCID: PMC6726455  PMID: 31517052
Ly, T., C. T. Pappas, D. Johnson, W. Schlecht, M. Colpan, V. E. Galkin, C. C. Gregorio, W-J. Dong, and A. S. Kostyukova, "Effects of cardiomyopathy-linked mutations K15N and R21H in tropomyosin on thin-filament regulation and pointed-end dynamics.", Mol Biol Cell, vol. 30, issue 2, pp. 268-281, 2019 01 15. PMCID: PMC6589558  PMID: 30462572

2018

Pappas, C. T., G. P. Farman, R. M. Mayfield, J. P. Konhilas, and C. C. Gregorio, "Cardiac-specific knockout of Lmod2 results in a severe reduction in myofilament force production and rapid cardiac failure.", J Mol Cell Cardiol, vol. 122, pp. 88-97, 2018 09. PMCID: PMC6324932  PMID: 30102883
Chu, M., S. Mares Novak, C. Cover, A. A. Wang, I. Royal Chinyere, E. B. Juneman, D. C. Zarnescu, P. Kin Wong, and C. C. Gregorio, "Increased Cardiac Arrhythmogenesis Associated With Gap Junction Remodeling With Upregulation of RNA-Binding Protein FXR1.", Circulation, vol. 137, issue 6, pp. 605-618, 2018 02 06. PMCID: PMC5809294  PMID: 29101288

2017

Henderson, C. A., C. G. Gomez, S. M. Novak, L. Mi-Mi, and C. C. Gregorio, "Overview of the Muscle Cytoskeleton.", Compr Physiol, vol. 7, issue 3, pp. 891-944, 2017 06 18. PMCID: PMC5890934  PMID: 28640448

2016

Ly, T., N. Moroz, C. T. Pappas, S. M. Novak, D. Tolkatchev, D. Wooldridge, R. M. Mayfield, G. Helms, C. C. Gregorio, and A. S. Kostyukova, "The N-terminal tropomyosin- and actin-binding sites are important for leiomodin 2's function.", Mol Biol Cell, vol. 27, issue 16, pp. 2565-75, 2016 08 15. PMCID: PMC4985258  PMID: 27307584
Chu, M., C. C. Gregorio, and C. T. Pappas, "Nebulin, a multi-functional giant.", J Exp Biol, vol. 219, issue Pt 2, pp. 146-52, 2016 Jan. PMCID: PMC6514474  PMID: 26792324

2015

Pappas, C. T., R. M. Mayfield, C. Henderson, N. Jamilpour, C. Cover, Z. Hernandez, K. R. Hutchinson, M. Chu, K-H. Nam, J. M. Valdez, et al., "Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality.", Proc Natl Acad Sci U S A, vol. 112, issue 44, pp. 13573-8, 2015 Nov 3. PMCID: PMC4640780  PMID: 26487682

2014

Yuen, M., S. A. Sandaradura, J. J. Dowling, A. S. Kostyukova, N. Moroz, K. G. Quinlan, V-L. Lehtokari, G. Ravenscroft, E. J. Todd, O. Ceyhan-Birsoy, et al., "Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.", J Clin Invest, vol. 124, issue 11, pp. 4693-708, 2014 Nov. PMCID: PMC4347224  PMID: 25250574

2013

Bliss, K. T., M. Chu, C. M. Jones-Weinert, and C. C. Gregorio, "Investigating lasp-2 in cell adhesion: new binding partners and roles in motility.", Mol Biol Cell, vol. 24, issue 7, pp. 995-1006, 2013 Apr. PMCID: PMC3608507  PMID: 23389630

2012

Leinwand, L. A., J. C. Tardiff, and C. C. Gregorio, "Mutations in the sensitive giant titin result in a broken heart.", Circ Res, vol. 111, issue 2, pp. 158-61, 2012 Jul 6. PMID: 22773424

2011

Whitman, S. A., C. Cover, L. Yu, D. L. Nelson, D. C. Zarnescu, and C. C. Gregorio, "Desmoplakin and talin2 are novel mRNA targets of fragile X-related protein-1 in cardiac muscle.", Circ Res, vol. 109, issue 3, pp. 262-71, 2011 Jul 22. PMCID: PMC3163600  PMID: 21659647