Christopher Pappas, PhD

Assistant Research Professor, Cellular and Molecular Medicine
Research Interests: 

My work is focused on understanding the mechanisms underlying actin filament assembly in striated muscle. Precise regulation of actin filament polarity, spacing and length is essential for proper muscle function and its dysregulation results in human myopathies. I'm specifically interested in how actin-binding proteins that reside at the ends of the filament cooperate to regulate its architecture. My research utilizes a combination of cellular, genetic, biochemical, molecular and biomechanical approaches.

Molecular Medicine Grad Program: 



Pappas, C. T., R. M. Mayfield, C. Henderson, N. Jamilpour, C. Cover, Z. Hernandez, K. R. Hutchinson, M. Chu, K-H. Nam, J. M. Valdez, et al., "Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality.", Proc Natl Acad Sci U S A, vol. 112, issue 44, pp. 13573-8, 2015 Nov 3. PMCID: PMC4640780  PMID: 26487682


Pappas, C. T., K. T. Bliss, A. Zieseniss, and C. C. Gregorio, "The Nebulin family: an actin support group.", Trends Cell Biol, vol. 21, issue 1, pp. 29-37, 2011 Jan. PMCID: PMC3014390  PMID: 20951588


Tsukada, T., C. T. Pappas, N. Moroz, P. B. Antin, A. S. Kostyukova, and C. C. Gregorio, "Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscle.", J Cell Sci, vol. 123, issue Pt 18, pp. 3136-45, 2010 Sep 15. PMCID: PMC2931607  PMID: 20736303
Pappas, C. T., P. A. Krieg, and C. C. Gregorio, "Nebulin regulates actin filament lengths by a stabilization mechanism.", J Cell Biol, vol. 189, issue 5, pp. 859-70, 2010 May 31. PMCID: PMC2878950  PMID: 20498015


Pappas, C. T., N. Bhattacharya, J. A. Cooper, and C. C. Gregorio, "Nebulin interacts with CapZ and regulates thin filament architecture within the Z-disc.", Mol Biol Cell, vol. 19, issue 5, pp. 1837-47, 2008 May. PMCID: PMC2366866  PMID: 18272787