Research in our laboratory is focused on understanding how aberrant structural organization of the cytoskeleton influences cellular behavior, such as cancer cell invasion and metastasis. The regulation of cellular behavior by structural remodeling of the cytoskeleton exemplifies the paradigm of “structure regulates function” at the cellular level. Our goal is to identify distinct actin cytoskeletal architectures that impact the response of cancer cells to well-known genetic and microenvironmental factors during cancer progression.
Ghassan (Gus) Mouneimne, PhD
Assistant Professor, Cellular and Molecular Medicine
Molecular Medicine Grad Program:
Carmona, G., U. Perera, C. Gillett, A. Naba, A-L. Law, V. P. Sharma, J. Wang, J. Wyckoff, M. Balsamo, F. Mosis, et al., "Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.", Oncogene, 2016 Mar 21. PMID: 26996666
Peela, N., F. S. Sam, W. Christenson, D. Truong, A. W. Watson, G. Mouneimne, R. Ros, and M. Nikkhah, "A three dimensional micropatterned tumor model for breast cancer cell migration studies.", Biomaterials, vol. 81, pp. 72-83, 2016 Mar. PMID: 26724455
Mouneimne, G., S. D. Hansen, L. M. Selfors, L. Petrak, M. M. Hickey, L. L. Gallegos, K. J. Simpson, J. Lim, F. B. Gertler, J. H. Hartwig, et al., "Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion.", Cancer Cell, vol. 22, issue 5, pp. 615-30, 2012 Nov 13. PMCID: PMC3500527 PMID: 23153535