Ghassan (Gus) Mouneimne, PhD

Associate Professor, Cellular and Molecular Medicine
Assistant Professor, Cancer Biology GIDP
Research Interests: 

Research in our laboratory is focused on understanding how aberrant structural organization of the cytoskeleton influences cellular behavior, such as cancer cell invasion and metastasis. The regulation of cellular behavior by structural remodeling of the cytoskeleton exemplifies the paradigm of “structure regulates function” at the cellular level. Our goal is to identify distinct actin cytoskeletal architectures that impact the response of cancer cells to well-known genetic and microenvironmental factors during cancer progression.

Molecular Medicine Grad Program: 
Yes

Bibliography

2019

Truong, D. D., A. Kratz, J. G. Park, E. S. Barrientos, H. Saini, T. Nguyen, B. Pockaj, G. Mouneimne, J. LaBaer, and M. Nikkhah, "A Human Organotypic Microfluidic Tumor Model Permits Investigation of the Interplay between Patient-Derived Fibroblasts and Breast Cancer Cells.", Cancer Res, vol. 79, issue 12, pp. 3139-3151, 2019 06 15. PMCID: PMC6664809  PMID: 30992322
Parker, S. S., J. Krantz, E-A. Kwak, N. K. Barker, C. G. Deer, N. Y. Lee, G. Mouneimne, and P. R. Langlais, "Insulin Induces Microtubule Stabilization and Regulates the Microtubule Plus-end Tracking Protein Network in Adipocytes.", Mol Cell Proteomics, vol. 18, issue 7, pp. 1363-1381, 2019 07 01. PMCID: PMC6601206  PMID: 31018989
Puleo, J. I., S. S. Parker, M. R. Roman, A. W. Watson, K. Rahmani Eliato, L. Peng, K. Saboda, D. J. Roe, R. Ros, F. B. Gertler, et al., "Mechanosensing during directed cell migration requires dynamic actin polymerization at focal adhesions.", J Cell Biol, vol. 218, issue 12, pp. 4215-4235, 2019 12 02. PMID: 31594807

2018

Nagaraju, S., D. Truong, G. Mouneimne, and M. Nikkhah, "Microfluidic Tumor-Vascular Model to Study Breast Cancer Cell Invasion and Intravasation.", Adv Healthc Mater, vol. 7, issue 9, pp. e1701257, 2018 05. PMID: 29334196
Padilla-Rodriguez, M., S. S. Parker, D. G. Adams, T. Westerling, J. I. Puleo, A. W. Watson, S. M. Hill, M. Noon, R. Gaudin, J. Aaron, et al., "The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion.", Nat Commun, vol. 9, issue 1, pp. 2980, 2018 07 30. PMCID: PMC6065369  PMID: 30061623
Parker, S. S., A. Moutal, S. Cai, S. Chandrasekaran, M. R. Roman, A. A. Koshy, R. Khanna, K. E. Zinsmaier, and G. Mouneimne, "High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons.", eNeuro, vol. 5, issue 5, 2018 Sep-Oct. PMCID: PMC6158653  PMID: 30263951

2017

Peela, N., E. S. Barrientos, D. Truong, G. Mouneimne, and M. Nikkhah, "Effect of suberoylanilide hydroxamic acid (SAHA) on breast cancer cells within a tumor-stroma microfluidic model.", Integr Biol (Camb), vol. 9, issue 12, pp. 988-999, 2017 Dec 11. PMID: 29188843

2016

Truong, D., J. Puleo, A. Llave, G. Mouneimne, R. D. Kamm, and M. Nikkhah, "Breast Cancer Cell Invasion into a Three Dimensional Tumor-Stroma Microenvironment.", Sci Rep, vol. 6, pp. 34094, 2016 Sep 28. PMCID: PMC5039718  PMID: 27678304
Carmona, G., U. Perera, C. Gillett, A. Naba, A-L. Law, V. P. Sharma, J. Wang, J. Wyckoff, M. Balsamo, F. Mosis, et al., "Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.", Oncogene, 2016 Mar 21. PMID: 26996666
Peela, N., F. S. Sam, W. Christenson, D. Truong, A. W. Watson, G. Mouneimne, R. Ros, and M. Nikkhah, "A three dimensional micropatterned tumor model for breast cancer cell migration studies.", Biomaterials, vol. 81, pp. 72-83, 2016 Mar. PMID: 26724455

2012

Hager, M. H., S. Morley, D. R. Bielenberg, S. Gao, M. Morello, I. N. Holcomb, W. Liu, G. Mouneimne, F. Demichelis, J. Kim, et al., "DIAPH3 governs the cellular transition to the amoeboid tumour phenotype.", EMBO Mol Med, vol. 4, issue 8, pp. 743-60, 2012 Aug. PMCID: PMC3494074  PMID: 22593025
Mouneimne, G., S. D. Hansen, L. M. Selfors, L. Petrak, M. M. Hickey, L. L. Gallegos, K. J. Simpson, J. Lim, F. B. Gertler, J. H. Hartwig, et al., "Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion.", Cancer Cell, vol. 22, issue 5, pp. 615-30, 2012 Nov 13. PMCID: PMC3500527  PMID: 23153535

2011

Kim, J. Hoon, A. Cho, H. Yin, D. A. Schafer, G. Mouneimne, K. J. Simpson, K-V. Nguyen, J. S. Brugge, and D. J. Montell, "Psidin, a conserved protein that regulates protrusion dynamics and cell migration.", Genes Dev, vol. 25, issue 7, pp. 730-41, 2011 Apr 1. PMCID: PMC3070935  PMID: 21406550