Henk Granzier, PhD

Professor, Cellular and Molecular Medicine
Professor, BIO5 Insitutue
Professor, Biomedical Engineering
Professor, Genetics GIDP
Professor, Molecular and Cellular Biology
Professor, Physiological Sciences GIDP
Professor, Physiology
Molecular Medicine Grad Program: 



Lindqvist, J., W. Ma, F. Li, Y. Hernandez, J. Kolb, B. Kiss, P. Tonino, R. van der Pijl, E. Karimi, H. Gong, et al., "Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism.", Nat Commun, vol. 11, issue 1, pp. 2699, 2020 Jun 01. PMID: 32483185


Brynnel, A., Y. Hernandez, B. Kiss, J. Lindqvist, M. Adler, J. Kolb, R. van der Pijl, J. Gohlke, J. Strom, J. Smith, et al., "Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy.", Elife, vol. 7, 2018 12 19. PMCID: PMC6300359  PMID: 30565562


Li, F., D. Buck, J. De Winter, J. Kolb, H. Meng, C. Birch, R. Slater, Y. Natelie Escobar, J. E. Smith, L. Yang, et al., "Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy.", Hum Mol Genet, vol. 24, issue 18, pp. 5219-33, 2015 Sep 15. PMCID: PMC4550825  PMID: 26123491


Granzier, H. L., K. R. Hutchinson, P. Tonino, M. Methawasin, F. W. Li, R. E. Slater, M. M. Bull, C. Saripalli, C. T. Pappas, C. C. Gregorio, et al., "Deleting titin's I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function.", Proc Natl Acad Sci U S A, vol. 111, issue 40, pp. 14589-94, 2014 Oct 7. PMCID: PMC4210014  PMID: 25246556
Methawasin, M., K. R. Hutchinson, E-J. Lee, J. E. Smith, C. Saripalli, C. G. Hidalgo, C. A. C. Ottenheijm, and H. Granzier, "Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole.", Circulation, vol. 129, issue 19, pp. 1924-36, 2014 May 13. PMCID: PMC4032222  PMID: 24599837


Lee, E-J., J. M. De Winter, D. Buck, J. R. Jasper, F. I. Malik, S. Labeit, C. A. Ottenheijm, and H. Granzier, "Fast skeletal muscle troponin activation increases force of mouse fast skeletal muscle and ameliorates weakness due to nebulin-deficiency.", PLoS One, vol. 8, issue 2, pp. e55861, 2013. PMCID: PMC3577798  PMID: 23437068
Anderson, B. R., J. Bogomolovas, S. Labeit, and H. Granzier, "Single molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism.", J Biol Chem, vol. 288, issue 8, pp. 5303-15, 2013 Feb 22. PMCID: PMC3581406  PMID: 23297410


Doetschman, T., J. V. Barnett, R. B. Runyan, T. D. Camenisch, R. L. Heimark, H. L. Granzier, S. J. Conway, and M. Azhar, "Transforming growth factor beta signaling in adult cardiovascular diseases and repair.", Cell Tissue Res, vol. 347, issue 1, pp. 203-23, 2012 Jan. PMCID: PMC3328790  PMID: 21953136


Makwana, O., N. M. P. King, L. Ahles, O. Selmin, H. L. Granzier, and R. B. Runyan, "Exposure to low-dose trichloroethylene alters shear stress gene expression and function in the developing chick heart.", Cardiovasc Toxicol, vol. 10, issue 2, pp. 100-7, 2010 Jun. PMCID: PMC3069695  PMID: 20186580