Lonnie Lybarger, PhD

Associate Professor, Cellular and Molecular Medicine
Associate Professor, Immunobiology
Associate Professor, BIO5 Institute
Research Interests: 

My research interests center on the cell biology of antigen presentation within the immune system. We study a family of virus-encoded immune evasion molecules that co-opt host ubiquitin-dependent intracellular trafficking pathways to inhibit antigen presentation. These pathways are explored using biochemical and cell biological techniques.

Molecular Medicine Grad Program: 



Wang, B., T. M. Primeau, N. Myers, H. W. Rohrs, M. L. Gross, L. Lybarger, T. H. Hansen, and J. M. Connolly, "A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire.", Science, vol. 326, issue 5954, pp. 871-4, 2009 Nov 6. PMCID: PMC2828816  PMID: 19892989
Jabbour, M., E. M. Campbell, H. Fares, and L. Lybarger, "Discrete domains of MARCH1 mediate its localization, functional interactions, and posttranscriptional control of expression.", J Immunol, vol. 183, issue 10, pp. 6500-12, 2009 Nov 15. PMCID: PMC2782856  PMID: 19880452
Corcoran, K., X. Wang, and L. Lybarger, "Adapter-mediated substrate selection for endoplasmic reticulum-associated degradation.", J Biol Chem, vol. 284, issue 26, pp. 17475-87, 2009 Jun 26. PMCID: PMC2719388  PMID: 19366690


Lybarger, L., X. Wang, M. R. Harris, H. W. Virgin, and T. H. Hansen, "Virus subversion of the MHC class I peptide-loading complex.", Immunity, vol. 18, issue 1, pp. 121-30, 2003 Jan. PMID: 12530981


Lybarger, L., Y. Y. Yu, T. Chun, C. R. Wang, A. G. Grandea, L. Van Kaer, and T. H. Hansen, "Tapasin enhances peptide-induced expression of H2-M3 molecules, but is not required for the retention of open conformers.", J Immunol, vol. 167, issue 4, pp. 2097-105, 2001 Aug 15. PMID: 11489993