Lonnie Lybarger, PhD

Associate Professor, Cellular and Molecular Medicine
Associate Professor, Immunobiology
Associate Professor, BIO5 Institute
Research Interests: 

My research interests center on the cell biology of antigen presentation within the immune system. We study a family of virus-encoded immune evasion molecules that co-opt host ubiquitin-dependent intracellular trafficking pathways to inhibit antigen presentation. These pathways are explored using biochemical and cell biological techniques.

Molecular Medicine Grad Program: 
Yes

Bibliography

2020

Jamwal, D. R., D. Laubitz, C. A. Harrison, V. Figliuolo da Paz, C. M. Cox, R. Wong, M. Midura-Kiela, M. A. Gurney, D. G. Besselsen, P. Setty, et al., "Intestinal Epithelial Expression of MHCII Determines Severity of Chemical, T-Cell-Induced, and Infectious Colitis in Mice.", Gastroenterology, vol. 159, issue 4, pp. 1342-1356.e6, 2020 10. PMID: 32589883

2018

Bhagwandin, C., E. L. Ashbeck, M. Whalen, J. Bandola-Simon, P. A. Roche, A. Szajman, S. Mai Truong, B. C. Wertheim, Y. C. Klimentidis, S. Ishido, et al., "The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner.", PLoS One, vol. 13, issue 10, pp. e0204898, 2018. PMCID: PMC6200199  PMID: 30356278

2013

Phipps-Yonas, H., H. Cui, N. Sebastiao, P. S. Brunhoeber, E. Haddock, M. J. Deymier, W. Klapper, L. Lybarger, D. J. Roe, and K. Taraszka Hastings, "Low GILT Expression is Associated with Poor Patient Survival in Diffuse Large B-Cell Lymphoma.", Front Immunol, vol. 4, pp. 425, 2013. PMCID: PMC3885809  PMID: 24409177

2011

Corcoran, K., M. Jabbour, C. Bhagwandin, M. J. Deymier, D. L. Theisen, and L. Lybarger, "Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1).", J Biol Chem, vol. 286, issue 43, pp. 37168-80, 2011 Oct 28. PMCID: PMC3199464  PMID: 21896490
Rizvi, S. Monem, N. Del Cid, L. Lybarger, and M. Raghavan, "Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules.", J Immunol, vol. 186, issue 4, pp. 2309-20, 2011 Feb 15. PMCID: PMC3057457  PMID: 21263072

2010

Ordaz, M. L., N. Larmonier, and L. Lybarger, "DC-expressed MHC class I single-chain trimer-based vaccines prime cytotoxic T lymphocytes against exogenous but not endogenous antigens.", Cell Immunol, vol. 262, issue 2, pp. 141-9, 2010. PMID: 20199770

2009

Wang, B., T. M. Primeau, N. Myers, H. W. Rohrs, M. L. Gross, L. Lybarger, T. H. Hansen, and J. M. Connolly, "A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire.", Science, vol. 326, issue 5954, pp. 871-4, 2009 Nov 6. PMCID: PMC2828816  PMID: 19892989
Jabbour, M., E. M. Campbell, H. Fares, and L. Lybarger, "Discrete domains of MARCH1 mediate its localization, functional interactions, and posttranscriptional control of expression.", J Immunol, vol. 183, issue 10, pp. 6500-12, 2009 Nov 15. PMCID: PMC2782856  PMID: 19880452
Corcoran, K., X. Wang, and L. Lybarger, "Adapter-mediated substrate selection for endoplasmic reticulum-associated degradation.", J Biol Chem, vol. 284, issue 26, pp. 17475-87, 2009 Jun 26. PMCID: PMC2719388  PMID: 19366690

2003

Lybarger, L., X. Wang, M. R. Harris, H. W. Virgin, and T. H. Hansen, "Virus subversion of the MHC class I peptide-loading complex.", Immunity, vol. 18, issue 1, pp. 121-30, 2003 Jan. PMID: 12530981

2001

Lybarger, L., Y. Y. Yu, T. Chun, C. R. Wang, A. G. Grandea, L. Van Kaer, and T. H. Hansen, "Tapasin enhances peptide-induced expression of H2-M3 molecules, but is not required for the retention of open conformers.", J Immunol, vol. 167, issue 4, pp. 2097-105, 2001 Aug 15. PMID: 11489993