Natalia Ignatenko, PhD

Associate Professor, Cellular and Molecular Medicine

Dr. Ignatenko obtained her Ph.D. at RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine. She completed her post-doctoral education at the University of Arizona, Tucson, USA. Dr. Ignatenko has a broad background in cancer biology with specific training in biochemistry of polyamines, and expertise in molecular biology of colorectal cancer and mouse models of cancer. She conducts research in the area of gastrointestinal malignancy with the goal of identifying and validating molecular markers and therapeutic targets of this disease.

Research Interests: 

 Kallikrein-related peptidases, role of polyamines in GI inflammation and malignancy. Discovery and validation of therapeutic targets of mutant APC tumor suppressor gene and K-RAS oncogene in colorectal cancer.

Molecular Medicine Grad Program: 
No

Bibliography

2021

Pandey, R., M. Zhou, Y. Chen, D. Darmoul, C. C. Kisiel, V. N. Nfonsam, and N. A. Ignatenko, "Molecular Pathways Associated with Kallikrein 6 Overexpression in Colorectal Cancer.", Genes (Basel), vol. 12, issue 5, 2021 05 16. PMCID: PMC8157155  PMID: 34065672

2020

De Vita, E., N. Smits, H. van den Hurk, E. M. Beck, J. Hewitt, G. Baillie, E. Russell, A. Pannifer, V. Hamon, A. Morrison, et al., "Synthesis and Structure-Activity Relationships of N-(4-Benzamidino)-Oxazolidinones: Potent and Selective Inhibitors of Kallikrein-Related Peptidase 6.", ChemMedChem, vol. 15, issue 1, pp. 79-95, 2020 01 07. PMCID: PMC7004151  PMID: 31675166

2019

Chen, H., E. Sells, R. Pandey, E. R. Abril, C-H. Hsu, R. S. Krouse, R. B. Nagle, G. Pampalakis, G. Sotiropoulou, and N. A. Ignatenko, "Kallikrein 6 protease advances colon tumorigenesis induction of the high mobility group A2 protein.", Oncotarget, vol. 10, issue 58, pp. 6062-6078, 2019 10 22. PMCID: PMC6817440  PMID: 31692974

2018

Sinharay, S., E. A. Randtke, C. M. Howison, N. A. Ignatenko, and M. D. Pagel, "Detection of Enzyme Activity and Inhibition during Studies in Solution, In Vitro and In Vivo with CatalyCEST MRI.", Mol Imaging Biol, vol. 20, issue 2, pp. 240-248, 2018 04. PMCID: PMC6010181  PMID: 28726131
Rice, P. F. S., K. G. Ehrichs, M. S. Jones, H. Chen, C-H. Hsu, E. R. Abril, R. B. Nagle, D. G. Besselsen, J. K. Barton, and N. A. Ignatenko, "Does Mutated Oncogene Attenuate the Effect of Sulindac in Colon Cancer Chemoprevention?", Cancer Prev Res (Phila), vol. 11, issue 1, pp. 16-26, 2018 01. PMCID: PMC7733710  PMID: 29118162

2017

Sells, E., R. Pandey, H. Chen, B. A. Skovan, H. Cui, and N. A. Ignatenko, "Specific microRNA-mRNA Regulatory Network of Colon Cancer Invasion Mediated by Tissue Kallikrein-Related Peptidase 6.", Neoplasia, vol. 19, issue 5, pp. 396-411, 2017 May. PMCID: PMC5397577  PMID: 28431272

2015

LeGendre-McGhee, S., P. S. Rice, A. R Wall, K. J. Sprute, R. Bommireddy, A. M. Luttman, R. B. Nagle, E. R. Abril, K. Farrell, C-H. Hsu, et al., "Time-serial Assessment of Drug Combination Interventions in a Mouse Model of Colorectal Carcinogenesis Using Optical Coherence Tomography.", Cancer Growth Metastasis, vol. 8, issue Suppl 1, pp. 63-80, 2015. PMCID: PMC4562605  PMID: 26396545
Padavano, J., R. S. Henkhaus, H. Chen, B. A. Skovan, H. Cui, and N. A. Ignatenko, "Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways.", Cancer Growth Metastasis, vol. 8, issue Suppl 1, pp. 95-113, 2015. PMCID: PMC4612127  PMID: 26512205
Yee, N. S., N. Ignatenko, N. Finnberg, N. Lee, and D. Stairs, "Animal Models of Cancer Biology", Cancer Growth Metastasis, vol. 8, issue Suppl 1, pp. 115-8, 2015. PMCID: PMC4676433  PMID: 26688665

2013

Roy, U. K. Basu, R. S. Henkhaus, F. Loupakis, C. Cremolini, E. W. Gerner, and N. A. Ignatenko, "Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis.", Int J Cancer, vol. 133, issue 1, pp. 43-57, 2013 Jul. PMCID: PMC3633716  PMID: 23280667
Ignatenko, N. A., and E. W. Gerner, "Get the fat out!", Cancer Prev Res (Phila), vol. 6, issue 3, pp. 161-4, 2013 Mar. PMCID: PMC3595132  PMID: 23466814

2011

Paz, E. A., J. Garcia-Huidobro, and N. A. Ignatenko, "Polyamines in cancer.", Adv Clin Chem, vol. 54, pp. 45-70, 2011. PMID: 21874756