R. Clark Lantz, PhD

Professor, Emeritus
Research Interests: 

My research focuses on the effects of in utero and early postnatal exposure to environmental toxicants on the lung. Data obtained from in vitro cell culture and in vivo animal models is subsequently translated into human population studies to validate responses and identify potential adverse health outcomes.

Molecular Medicine Grad Program: 



Chau, B., M. L. Witten, D. Cromey, Y. Chen, and C. R Lantz, "Lung developmental is altered after inhalation exposure to various concentrations of calcium arsenate.", Toxicol Appl Pharmacol, vol. 432, pp. 115754, 2021 Oct 09. PMID: 34634286


Witten, M. L., B. Chau, E. Sáez, S. Boitano, and C. R Lantz, "Early life inhalation exposure to mine tailings dust affects lung development.", Toxicol Appl Pharmacol, vol. 365, pp. 124-132, 2019 02 15. PMCID: PMC6349506  PMID: 30641074


Yellowhair, M., M. R. Romanotto, D. M. Stearns, and C. R Lantz, "Uranyl acetate induced DNA single strand breaks and AP sites in Chinese hamster ovary cells.", Toxicol Appl Pharmacol, vol. 349, pp. 29-38, 2018 06 15. PMCID: PMC5972677  PMID: 29698738
Thomas, A. N., R. A. Root, C. R Lantz, E. A Sáez, and J. Chorover, "Oxidative weathering decreases bioaccessibility of toxic metal(loid)s in PM emissions from sulfide mine tailings.", Geohealth, vol. 2, issue 4, pp. 118-138, 2018 Apr. PMCID: PMC6191178  PMID: 30338309


Smeester, L., P. A. Bommarito, E. M. Martin, R. Recio-Vega, T. Gonzalez-Cortes, E. Olivas-Calderon, C. R Lantz, and R. C. Fry, "Chronic early childhood exposure to arsenic is associated with a TNF-mediated proteomic signaling response.", Environ Toxicol Pharmacol, vol. 52, pp. 183-187, 2017 Jun. PMCID: PMC5796657  PMID: 28433805
Michel-Ramirez, G., R. Recio-Vega, G. Ocampo-Gomez, E. Palacios-Sanchez, M. Delgado-Macias, M. Delgado-Gaona, R. Clark Lantz, J. Gandolfi, and T. Gonzalez-Cortes, "Association between YAP expression in neoplastic and non-neoplastic breast tissue with arsenic urinary levels.", J Appl Toxicol, vol. 37, issue 10, pp. 1195-1202, 2017 Oct. PMCID: PMC5790116  PMID: 28524356
Gonzalez-Cortes, T., R. Recio-Vega, R. Clark Lantz, and B. T. Chau, "DNA methylation of extracellular matrix remodeling genes in children exposed to arsenic.", Toxicol Appl Pharmacol, vol. 329, pp. 140-147, 2017 08 15. PMCID: PMC5806512  PMID: 28579250


de la Vega, M. Rojo, M. Dodson, C. Gross, H. M. Mansour, C. R Lantz, E. Chapman, T. Wang, S. M. Black, J. G. N. Garcia, and D. D. Zhang, "Role of Nrf2 and Autophagy in Acute Lung Injury.", Curr Pharmacol Rep, vol. 2, issue 2, pp. 91-101, 2016 04. PMCID: PMC4905711  PMID: 27313980
Beamer, P. I., W. T. Klimecki, M. Loh, Y. Ornelas Van Horne, A. J. Sugeng, N. Lothrop, D. Billheimer, S. Guerra, R. Clark Lantz, R. A. Canales, et al., "Association of Children's Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media.", Int J Environ Res Public Health, vol. 13, issue 5, 2016 05 23. PMCID: PMC4881146  PMID: 27223295


Recio-Vega, R., T. Gonzalez-Cortes, E. Olivas-Calderon, C. R Lantz, J. A Gandolfi, and C. Gonzalez- De Alba, "In utero and early childhood exposure to arsenic decreases lung function in children.", J Appl Toxicol, vol. 35, issue 4, pp. 358-66, 2015 Apr. PMCID: PMC4750377  PMID: 25131850
Olivas-Calderon, E., R. Recio-Vega, J. A Gandolfi, C. R Lantz, T. Gonzalez-Cortes, C. Gonzalez- De Alba, J. R. Froines, and J. A. Espinosa-Fematt, "Lung inflammation biomarkers and lung function in children chronically exposed to arsenic.", Toxicol Appl Pharmacol, vol. 287, issue 2, pp. 161-167, 2015 Sep 01. PMCID: PMC4751871  PMID: 26048584


Sherwood, C. L., A. E. Liguori, C. E. Olsen, C. R Lantz, J. L. Burgess, and S. Boitano, "Arsenic compromises conducting airway epithelial barrier properties in primary mouse and immortalized human cell cultures.", PLoS One, vol. 8, issue 12, pp. e82970, 2013. PMCID: PMC3857810  PMID: 24349408
Sherwood, C. L., C. R Lantz, and S. Boitano, "Chronic arsenic exposure in nanomolar concentrations compromises wound response and intercellular signaling in airway epithelial cells.", Toxicol Sci, vol. 132, issue 1, pp. 222-34, 2013 Mar. PMCID: PMC3576008  PMID: 23204110


R Lantz, C., B. Chau, P. Sarihan, M. L. Witten, V. I. Pivniouk, and G. Jie Chen, "In utero and postnatal exposure to arsenic alters pulmonary structure and function.", Toxicol Appl Pharmacol, vol. 235, issue 1, pp. 105-13, 2009 Feb 15. PMCID: PMC2669654  PMID: 19095001