Raymond B. Runyan, PhD

Professor, Emeritus
Research Interests: 

Research in my laboratory centers on the biological process of Epithelial-Mesenchymal Transition (EMT). Valve formation the embryonic heart begins with a localized EMT that produces the progenitors of valve cells. EMT is also a component of cancer metastasis. Recent work focuses on novel regulators of EMT found in embryo and tumor tissues.

Molecular Medicine Grad Program: 
Yes

Bibliography

2020

Yang, J., P. Antin, G. Berx, C. Blanpain, T. Brabletz, M. Bronner, K. Campbell, A. Cano, J. Casanova, G. Christofori, et al., "Guidelines and definitions for research on epithelial-mesenchymal transition.", Nat Rev Mol Cell Biol, vol. 21, issue 6, pp. 341-352, 2020 Jun. PMID: 32300252
Chen, S., A. Lencinas, M. Nunez, O. I. Selmin, and R. B. Runyan, "HNF4a transcription is a target of trichloroethylene toxicity in the embryonic mouse heart.", Environ Sci Process Impacts, vol. 22, issue 3, pp. 824-832, 2020 Mar 01. PMCID: PMC7250168  PMID: 32159184
Yuan, C., X. Zhao, Z. Wang, T. K. Borg, T. Ye, Z. I. Khalpey, R. B. Runyan, Y. Shao, and B. Z. Gao, "Study of the Expression Transition of Cardiac Myosin Using Polarization-Dependent SHG Microscopy.", Biophys J, vol. 118, issue 5, pp. 1058-1066, 2020 Mar 10. PMCID: PMC7063480  PMID: 31995740

2019

Runyan, R. B., O. I. Selmin, S. M. Smith, and J. L. Freeman, "Letter to the Editor.", Birth Defects Res, vol. 111, issue 16, pp. 1234-1236, 2019 10 01. PMID: 31385457
Yuan, C., Z. Wang, T. K. Borg, T. Ye, C. Baicu, A. Bradshaw, M. Zile, R. B. Runyan, Y. Shao, and B. Z. Gao, "Changes in the crystallographic structures of cardiac myosin filaments detected by polarization-dependent second harmonic generation microscopy.", Biomed Opt Express, vol. 10, issue 7, pp. 3183-3195, 2019 Jul 01. PMCID: PMC6640825  PMID: 31360597
Nfonsam, V. N., L. E. Nfonsam, D. Chen, P. N. Omesiete, A. Cruz, R. B. Runyan, and J. Jandova, "COMP Gene Coexpresses With EMT Genes and Is Associated With Poor Survival in Colon Cancer Patients.", J Surg Res, vol. 233, pp. 297-303, 2019 01. PMID: 30502262

2018

Avery, R. J., S. K. Yu, G. Cherukuri, R. B. Runyan, J. Konhilas, and Z. I. Khalpey, "Remodeling Failing Human Myocardium With Hybrid Cell/Matrix and Transmyocardial Revascularization.", ASAIO J, vol. 64, issue 5, pp. e130-e133, 2018 Sep/Oct. PMID: 29189425
Harris, A. P., K. A. Ismail, M. Nunez, I. Martopullo, A. Lencinas, O. I. Selmin, and R. B. Runyan, "Trichloroethylene perturbs HNF4a expression and activity in the developing chick heart.", Toxicol Lett, vol. 285, pp. 113-120, 2018 Mar 15. PMCID: PMC5803365  PMID: 29306027
Tavares, A. L. P., J. A. Brown, E. C. Ulrich, K. Dvorak, and R. B. Runyan, "Runx2-I is an Early Regulator of Epithelial-Mesenchymal Cell Transition in the Chick Embryo.", Dev Dyn, vol. 247, issue 3, pp. 542-554, 2018 Mar. PMCID: PMC5736463  PMID: 28631378
Runyan, R. B., and P. Savagner, "Epithelial-mesenchymal transition and plasticity in the developmental basis of cancer and fibrosis.", Dev Dyn, vol. 247, issue 3, pp. 330-331, 2018 Mar. PMID: 29446197

2017

Iwanski, J., S. M. Knapp, R. Avery, I. Oliva, R. K. Wong, R. B. Runyan, and Z. Khalpey, "Clinical outcomes meta-analysis: measuring subendocardial perfusion and efficacy of transmyocardial laser revascularization with nuclear imaging.", J Cardiothorac Surg, vol. 12, issue 1, pp. 37, 2017 May 19. PMCID: PMC5438520  PMID: 28526044
Kazui, T., P. L. Tran, T. R. Pilikian, K. M. Marsh, R. Runyan, J. Konhilas, R. Smith, and Z. I. Khalpey, "A dual therapy of off-pump temporary left ventricular extracorporeal device and amniotic stem cell for cardiogenic shock.", J Cardiothorac Surg, vol. 12, issue 1, pp. 80, 2017 Sep 07. PMCID: PMC5588547  PMID: 28882138
Ferng, A., A. Connell, M. Nunez, K. Johnson, B. Braunhut, S. Lick, A. Desai, T. Kazui, R. Runyan, and Z. Khalpey, "Cardiac Regeneration in the Human Left Ventricle After CorMatrix Implantation.", Ann Thorac Surg, vol. 104, issue 3, pp. e239-e241, 2017 Sep. PMID: 28838516
Schipper, D. A., A. V. Louis, D. S. Dicken, K. Johnson, R. T. Smolenski, S. M. Black, R. Runyan, J. Konhilas, J. G. N. Garcia, and Z. Khalpey, "Improved metabolism and redox state with a novel preservation solution: implications for donor lungs after cardiac death (DCD).", Pulm Circ, vol. 7, issue 2, pp. 494-504, 2017 Apr-Jun. PMCID: PMC5467941  PMID: 28597777

2016

Ferng, A. S., K. M. Marsh, J. M. Fleming, R. F. Conway, D. Schipper, N. Bajaj, A. M. Connell, T. Pilikian, K. Johnson, R. Runyan, et al., "Adipose-derived human stem/stromal cells: comparative organ specific mitochondrial bioenergy profiles.", Springerplus, vol. 5, issue 1, pp. 2057, 2016. PMCID: PMC5133220  PMID: 27995034
Yang, H., T. K. Borg, Z. Ma, M. Xu, G. Wetzel, L. V. Saraf, R. Markwald, R. B. Runyan, and B. Z. Gao, "Biochip-based study of unidirectional mitochondrial transfer from stem cells to myocytes via tunneling nanotubes.", Biofabrication, vol. 8, issue 1, pp. 015012, 2016 Mar. PMID: 26844857
Yang, H., L. P. Schmidt, Z. Wang, X. Yang, Y. Shao, T. K. Borg, R. Markwald, R. Runyan, and B. Z. Gao, "Dynamic Myofibrillar Remodeling in Live Cardiomyocytes under Static Stretch.", Sci Rep, vol. 6, pp. 20674, 2016 Feb 10. PMCID: PMC4748238  PMID: 26861590
Iwanski, J., R. K. Wong, D. F. Larson, A. S. Ferng, R. B. Runyan, S. Goldstein, and Z. Khalpey, "Remodeling an infarcted heart: novel hybrid treatment with transmyocardial revascularization and stem cell therapy.", Springerplus, vol. 5, issue 1, pp. 738, 2016. PMCID: PMC4909685  PMID: 27376006

2015

Cox, C. M., E. K. Mandell, L. Stewart, R. Lu, D. L. Johnson, S. D. McCarter, A. Tavares, R. Runyan, S. Ghosh, and J. M. Wilson, "Endosomal regulation of contact inhibition through the AMOT:YAP pathway.", Mol Biol Cell, vol. 26, issue 14, pp. 2673-84, 2015 Jul 15. PMCID: PMC4501364  PMID: 25995376

2013

Lencinas, A., D. C. Chhun, K. P. Dan, K. D. Ross, E. A. Hoover, P. B. Antin, and R. B. Runyan, "Olfactomedin-1 activity identifies a cell invasion checkpoint during epithelial-mesenchymal transition in the chick embryonic heart.", Dis Model Mech, vol. 6, issue 3, pp. 632-42, 2013 May. PMCID: PMC3634647  PMID: 23264563
Ma, Z., H. Yang, H. Liu, M. Xu, R. B. Runyan, C. A. Eisenberg, R. R. Markwald, T. K. Borg, and B. Z. Gao, "Mesenchymal stem cell-cardiomyocyte interactions under defined contact modes on laser-patterned biochips.", PLoS One, vol. 8, issue 2, pp. e56554, 2013. PMCID: PMC3572044  PMID: 23418583
Makwana, O., L. Ahles, A. Lencinas, O. I. Selmin, and R. B. Runyan, "Low-dose trichloroethylene alters cytochrome P450-2C subfamily expression in the developing chick heart.", Cardiovasc Toxicol, vol. 13, issue 1, pp. 77-84, 2013 Mar. PMCID: PMC3927724  PMID: 22855351
Liu, H., Y. Shao, W. Qin, R. B. Runyan, M. Xu, Z. Ma, T. K. Borg, R. Markwald, and B. Z. Gao, "Myosin filament assembly onto myofibrils in live neonatal cardiomyocytes observed by TPEF-SHG microscopy.", Cardiovasc Res, vol. 97, issue 2, pp. 262-70, 2013 Feb 01. PMCID: PMC3543992  PMID: 23118131
Ma, Z., Q. Liu, H. Yang, R. B. Runyan, C. A. Eisenberg, M. Xu, T. K. Borg, R. Markwald, Y. Wang, and B. Z. Gao, "Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level.", Light Sci Appl, vol. 2, 2013. PMCID: PMC3920285  PMID: 24527266

2012

Doetschman, T., J. V. Barnett, R. B. Runyan, T. D. Camenisch, R. L. Heimark, H. L. Granzier, S. J. Conway, and M. Azhar, "Transforming growth factor beta signaling in adult cardiovascular diseases and repair.", Cell Tissue Res, vol. 347, issue 1, pp. 203-23, 2012 Jan. PMCID: PMC3328790  PMID: 21953136

2011

Thompson, E. W., R. Runyan, P. Savagner, and D. F. Newgreen, "Out of the desert: the 4th TEMTIA Meeting on new advances in development, fibrosis and cancer.", Cells Tissues Organs, vol. 193, issue 1-2, pp. 4-7, 2011. PMID: 21051880
Lencinas, A., A. L. P. Tavares, J. V. Barnett, and R. B. Runyan, "Collagen gel analysis of epithelial-mesenchymal transition in the embryo heart: an in vitro model system for the analysis of tissue interaction, signal transduction, and environmental effects.", Birth Defects Res C Embryo Today, vol. 93, issue 4, pp. 298-311, 2011 Dec. PMID: 22271679

2010

Lencinas, A., D. M. Broka, J. H. Konieczka, S. E. Klewer, P. B. Antin, T. D. Camenisch, and R. B. Runyan, "Arsenic exposure perturbs epithelial-mesenchymal cell transition and gene expression in a collagen gel assay.", Toxicol Sci, vol. 116, issue 1, pp. 273-85, 2010 Jul. PMCID: PMC2886855  PMID: 20308225
Makwana, O., N. M. P. King, L. Ahles, O. Selmin, H. L. Granzier, and R. B. Runyan, "Exposure to low-dose trichloroethylene alters shear stress gene expression and function in the developing chick heart.", Cardiovasc Toxicol, vol. 10, issue 2, pp. 100-7, 2010 Jun. PMCID: PMC3069695  PMID: 20186580
Caldwell, P. T., A. Manziello, J. Howard, B. Palbykin, R. B. Runyan, and O. Selmin, "Gene expression profiling in the fetal cardiac tissue after folate and low-dose trichloroethylene exposure.", Birth Defects Res A Clin Mol Teratol, vol. 88, issue 2, pp. 111-27, 2010 Feb. PMCID: PMC4045246  PMID: 19813261

2006

Doyle, S. E., M. J. Scholz, K. A. Greer, A. D. Hubbard, D. K. Darnell, P. B. Antin, S. E. Klewer, and R. B. Runyan, "Latrophilin-2 is a novel component of the epithelial-mesenchymal transition within the atrioventricular canal of the embryonic chicken heart.", Dev Dyn, vol. 235, issue 12, pp. 3213-21, 2006 Dec. PMID: 17016846

2000

Romano, L. A., and R. B. Runyan, "Slug is an essential target of TGFbeta2 signaling in the developing chicken heart.", Dev Biol, vol. 223, issue 1, pp. 91-102, 2000 Jul 01. PMID: 10864463
Boyer, A. S., W. T. Finch, and R. B. Runyan, "Trichloroethylene inhibits development of embryonic heart valve precursors in vitro.", Toxicol Sci, vol. 53, issue 1, pp. 109-17, 2000 Jan. PMID: 10653528

1999

Brown, C. B., A. S. Boyer, R. B. Runyan, and J. V. Barnett, "Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart.", Science, vol. 283, issue 5410, pp. 2080-2, 1999 Mar 26. PMID: 10092230

1991

Potts, J. D., J. M. Dagle, J. A. Walder, D. L. Weeks, and R. B. Runyan, "Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by a modified antisense oligodeoxynucleotide to transforming growth factor beta 3.", Proc Natl Acad Sci U S A, vol. 88, issue 4, pp. 1516-20, 1991 Feb 15. PMCID: PMC51050  PMID: 1996351

1989

Potts, J. D., and R. B. Runyan, "Epithelial-mesenchymal cell transformation in the embryonic heart can be mediated, in part, by transforming growth factor beta.", Dev Biol, vol. 134, issue 2, pp. 392-401, 1989 Aug. PMID: 2744239

1983

Runyan, R. B., and R. R. Markwald, "Invasion of mesenchyme into three-dimensional collagen gels: a regional and temporal analysis of interaction in embryonic heart tissue.", Dev Biol, vol. 95, issue 1, pp. 108-14, 1983 Jan. PMID: 6825921