Tom Doetschman, PhD

Professor, Cellular and Molecular Medicine
Professor, BIO5 Institute
Professor, Cancer Biology GIDP
Professor, Genetics GIDP
Research Interests: 

Genetically engineered mice with mutations in TGFßs and FGF2 are being used by my laboratory. This has resulted in models for the following human diseases: autoimmune disease, colon cancer, congenital heart defects and cardiac hypertrophy. These models are providing a better understanding of these diseases and the roles that TGFß and FGF2 play in their development.

Molecular Medicine Grad Program: 
No

Bibliography

2016

Samadder, P., N. Weng, T. Doetschman, R. L. Heimark, and D. W. Galbraith, "Flow cytometry and single nucleus sorting for Cre-based analysis of changes in transcriptional states.", Cytometry A, 2016 Mar 22. PMID: 27003621

2015

Ardila, D. C., E. Tamimi, F. L. Danford, D. G. Haskett, R. S. Kellar, T. Doetschman, and J. P. Vande Geest, "TGFβ2 differentially modulates smooth muscle cell proliferation and migration in electrospun gelatin-fibrinogen constructs.", Biomaterials, vol. 37, pp. 164-73, 2015 Jan. PMCID: PMC4312204  PMID: 25453947

2012

Doetschman, T., and M. Azhar, "Cardiac-specific inducible and conditional gene targeting in mice.", Circ Res, vol. 110, issue 11, pp. 1498-512, 2012 May 25. PMCID: PMC3855383  PMID: 22628574

1997

Sanford, L. P., I. Ormsby, A. C. Gittenbe de Groot, H. Sariola, R. Friedman, G. P. Boivin, E. L. Cardell, and T. Doetschman, "TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes.", Development, vol. 124, issue 13, pp. 2659-70, 1997 Jul. PMCID: PMC3850286  PMID: 9217007

1995

Proetzel, G., S. A. Pawlowski, M. V. Wiles, M. Yin, G. P. Boivin, P. N. Howles, J. Ding, M. W. Ferguson, and T. Doetschman, "Transforming growth factor-beta 3 is required for secondary palate fusion.", Nat Genet, vol. 11, issue 4, pp. 409-14, 1995 Dec. PMCID: PMC3855390  PMID: 7493021

1992

Shull, M. M., I. Ormsby, A. B. Kier, S. Pawlowski, R. J. Diebold, M. Yin, R. Allen, C. Sidman, G. Proetzel, and D. Calvin, "Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease.", Nature, vol. 359, issue 6397, pp. 693-9, 1992 Oct 22. PMCID: PMC3889166  PMID: 1436033