Yana Zavros, PhD

Professor, Cellular and Molecular Medicine
Associate Head for Research

The Zavros lab studies of the mechanisms that drive gastric epithelial regeneration and Helicobacter pylori-induced disease using in vitro and in vivo organoid systems.  The lab has also developed patient-derived gastric and pancreatic cancer organoids from tumors and biopsies, which are used in personalized drug screens to predict individual therapy response.  Organoid/immune cell co-cultures and humanized mouse models are specifically used to identify the mechanisms by which cancer and immune cells foster an immunosuppressive tumor microenvironment.

Molecular Medicine Grad Program: 
Yes

Bibliography

2019

Wroblewski, L. E., E. Choi, C. Petersen, A. G. Delgado, B. M Piazuelo, J. Romero-Gallo, T. L. Lantz, Y. Zavros, R. J. Coffey, J. R. Goldenring, et al., "Targeted mobilization of Lrig1 gastric epithelial stem cell populations by a carcinogenic type IV secretion system.", Proc Natl Acad Sci U S A, vol. 116, issue 39, pp. 19652-19658, 2019 09 24. PMCID: PMC6765285  PMID: 31488717
Capurro, M. I., L. K. Greenfield, A. Prashar, S. Xia, M. Abdullah, H. Wong, X. Zoe Zhong, N. Bertaux-Skeirik, J. Chakrabarti, I. Siddiqui, et al., "VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1.", Nat Microbiol, vol. 4, issue 8, pp. 1411-1423, 2019 08 01. PMID: 31110360
Holokai, L., J. Chakrabarti, T. Broda, J. Chang, J. A. Hawkins, N. Sundaram, L. E. Wroblewski, R. M. Peek, J. Wang, M. Helmrath, et al., "Increased Programmed Death-Ligand 1 is an Early Epithelial Cell Response to Helicobacter pylori Infection.", PLoS Pathog, vol. 15, issue 1, pp. e1007468, 2019 01 01. PMCID: PMC6380601  PMID: 30703170
Bertaux-Skeirik, N., J. Centeno, J. Gao, J. Gabre, and Y. Zavros, "Oncogenic Transformation of Human-Derived Gastric Organoids.", Methods Mol Biol, vol. 1576, pp. 205-213, 2019 01 01. PMID: 27539460
Steele, N. G., J. Chakrabarti, J. Wang, J. Biesiada, L. Holokai, J. Chang, L. M. Nowacki, J. Hawkins, M. Mahe, N. Sundaram, et al., "An Organoid-Based Preclinical Model of Human Gastric Cancer.", Cell Mol Gastroenterol Hepatol, vol. 7, issue 1, pp. 161-184, 2019 01 01. PMCID: PMC6279812  PMID: 30522949
Noto, J. M., K. L. Rose, A. J. Hachey, A. G. Delgado, J. Romero-Gallo, L. E. Wroblewski, B. G. Schneider, S. C. Shah, T. L. Cover, K. T. Wilson, et al., "Carcinogenic Strains Selectively Dysregulate the Gastric Proteome, Which May Be Associated with Stomach Cancer Progression.", Mol Cell Proteomics, vol. 18, issue 2, pp. 352-371, 2019 02 01. PMCID: PMC6356085  PMID: 30455363

2018

Teal, E., N. Bertaux-Skeirik, J. Chakrabarti, L. Holokai, and Y. Zavros, "Establishment of Human- and Mouse-Derived Gastric Primary Epithelial Cell Monolayers from Organoids.", Methods Mol Biol, vol. 1817, pp. 145-155, 2018. PMID: 29959711
Teal, E., N. G. Steele, J. Chakrabarti, L. Holokai, and Y. Zavros, "Mouse- and Human-derived Primary Gastric Epithelial Monolayer Culture for the Study of Regeneration.", J Vis Exp, issue 135, 2018 05 07. PMCID: PMC6101118  PMID: 29782013
Zavros, Y., "The Novel Role of as a Regulator of Cell Homeostasis and Disease of the Gastric Oxyntic Mucosa.", Cell Mol Gastroenterol Hepatol, vol. 5, issue 4, pp. 645-646, 2018. PMCID: PMC5924750  PMID: 29713667
Chakrabarti, J., L. Holokai, LJ. Syu, N. G. Steele, J. Chang, J. Wang, S. Ahmed, A. Dlugosz, and Y. Zavros, "Hedgehog signaling induces PD-L1 expression and tumor cell proliferation in gastric cancer.", Oncotarget, vol. 9, issue 100, pp. 37439-37457, 2018 Dec 21. PMCID: PMC6324774  PMID: 30647844
Chakrabarti, J., L. Holokai, LJ. Syu, N. Steele, J. Chang, A. Dlugosz, and Y. Zavros, "Mouse-Derived Gastric Organoid and Immune Cell Co-culture for the Study of the Tumor Microenvironment.", Methods Mol Biol, vol. 1817, pp. 157-168, 2018. PMID: 29959712

2017

Zavros, Y., "Initiation and Maintenance of Gastric Cancer: A Focus on CD44 Variant Isoforms and Cancer Stem Cells.", Cell Mol Gastroenterol Hepatol, vol. 4, issue 1, pp. 55-63, 2017 Jul. PMCID: PMC5439237  PMID: 28560289
Bertaux-Skeirik, N., M. Wunderlich, E. Teal, J. Chakrabarti, J. Biesiada, M. Mahe, N. Sundaram, J. Gabre, J. Hawkins, G. Jian, et al., "CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium.", J Pathol, vol. 242, issue 4, pp. 463-475, 2017 08. PMCID: PMC5591948  PMID: 28497484
Braune, J., U. Weyer, M. Matz-Soja, C. Hobusch, M. Kern, A. Kunath, N. Klöting, S. Kralisch, M. Blüher, R. Gebhardt, et al., "Hedgehog signalling in myeloid cells impacts on body weight, adipose tissue inflammation and glucose metabolism.", Diabetologia, vol. 60, issue 5, pp. 889-899, 2017 05. PMID: 28233033