Julie Ledford, PhD

Associate Professor, Cellular and Molecular Medicine
Associate Professor, Immunobiology
Associate Professor, BIO5 Institute
Associate Professor, Clinical Translational Sciences

I am an Associate Professor with tenure in the Department of Cellular and Molecular Medicine at the University of Arizona. I am also an active member of the Asthma and Airway Disease Research Center and the BIO5 Institute and have faculty appointments in the Graduate Interdisciplinary Program in the Physiological Sciences and in the Allergy and Immunology Fellowship Training program. I serve as co-director of the Lung Research Focus group (RGF2) within the Southwest Environmental Health Sciences Center. I have over a decade’s worth of experience mentoring and training medical students, graduate students, postdocs and fellows. In addition, I participate as a faculty member and served on the curriculum committee for the Eureka Institute Virtual School, an international certificate program in translational research, and I serve as the leader for the University of Arizona College of Medicine hub. My own translational research investigates obstructive lung disease and dysfunction of innate immunity in Asthma and respiratory infections.  I have led pulmonary function tests with collaborators for the past 10 years and have a strong history of collaborations in the fields of respiratory diseases, lung function and asthma.

Research Interests: 

Our current work involves studies of pulmonary surfactant protein-A (SP-A), surfactant lipids, and club cell secretory protein (CC16) and how they participate in pulmonary diseases and immune system regulation. With a special emphasis on lung infections and asthma, we use a combination of animal modeling and human cells to better understand the roles of these endogenous lung proteins to overall host defense and lung homeostasis.

 

Molecular Medicine Grad Program: 
Yes

Bibliography

2021

Pederson, W. P., J. M. Cyphert-Daly, R. M. Tighe, L. G. Que, and J. G. Ledford, "Genetic variation in surfactant protein-A2 alters responses to ozone.", PLoS One, vol. 16, issue 2, pp. e0247504, 2021. PMCID: PMC7899376  PMID: 33617569
Polverino, F., T. David Wu, J. Rojas-Quintero, X. Wang, J. Mayo, M. Tomchaney, J. Tram, S. Packard, D. Zhang, K. H. Cleveland, et al., "Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment.", Am J Respir Crit Care Med, 2021 May 25. PMID: 34033525
Eedara, B. Babu, W. Alabsi, D. Encinas-Basurto, R. Polt, J. G. Ledford, and H. M. Mansour, "Inhalation Delivery for the Treatment and Prevention of COVID-19 Infection.", Pharmaceutics, vol. 13, issue 7, 2021 Jul 14. PMCID: PMC8308954  PMID: 34371768
Tomchaney, M., M. Contoli, J. Mayo, S. Baraldo, S. Li, C. R. Cabel, D. A. Bull, S. Lick, J. Malo, S. Knoper, et al., "Paradoxical effects of cigarette smoke and COPD on SARS-CoV-2 infection and disease.", BMC Pulm Med, vol. 21, issue 1, pp. 275, 2021 Aug 23. PMCID: PMC8381712  PMID: 34425811

2020

Johnson, M. D., U. S. Younis, S. V. Menghani, K. J. Addison, M. Whalen, A. L. Pilon, A. E. Cress, F. Polverino, C. Romanoski, M. Kraft, et al., "CC16 Binding to α4β1 Integrin (VLA-4) Protects Against Infection.", Am J Respir Crit Care Med, 2020 Dec 16. PMID: 33326355
Dy, A. B. C., and J. G. Ledford, "IL-13Rα2 Glycosylation Holds the Dance Card for Partnering with IL-13.", Am J Respir Cell Mol Biol, vol. 63, issue 3, pp. 277-278, 2020 09. PMCID: PMC7462345  PMID: 32459972
Francisco, D., Y. Wang, M. Conway, A. N. Hurbon, A. B. C. Dy, K. J. Addison, H. W. Chu, D. R. Voelker, J. G. Ledford, and M. Kraft, "Surfactant Protein-A Protects against IL-13-Induced Inflammation in Asthma.", J Immunol, vol. 204, issue 10, pp. 2829-2839, 2020 05 15. PMCID: PMC7304346  PMID: 32245819
Dakhama, A., R. Al Mubarak, N. Pavelka, D. Voelker, M. Seibold, J. G. Ledford, M. Kraft, L. Li, and H. Wei Chu, "Tollip Inhibits ST2 Signaling in Airway Epithelial Cells Exposed to Type 2 Cytokines and Rhinovirus.", J Innate Immun, vol. 12, issue 1, pp. 103-115, 2020. PMCID: PMC6959119  PMID: 30928973
Muralidharan, P., E. K. Mallory, M. Malapit, H. Phan, J. G. Ledford, D. Hayes, and H. M. Mansour, "Advanced design and development of nanoparticle/microparticle dual-drug combination lactose carrier-free dry powder inhalation aerosols.", RSC Adv, vol. 10, issue 68, pp. 41846-41856, 2020 Nov 17. PMCID: PMC7689944  PMID: 33391731
Younis, U. S., H. Wei Chu, M. Kraft, and J. G. Ledford, "A 20-Mer Peptide Derived from the Lectin Domain of Decreases Tumor Necrosis Factor Alpha Production during Mycoplasma pneumoniae Infection.", Infect Immun, vol. 88, issue 9, 2020 08 19. PMCID: PMC7440763  PMID: 32513852

2019

Zhai, J., M. Insel, K. J. Addison, D. A. Stern, W. Pederson, A. Dy, J. Rojas-Quintero, C. A. Owen, D. L. Sherrill, W. Morgan, et al., "Club Cell Secretory Protein Deficiency Leads to Altered Lung Function.", Am J Respir Crit Care Med, vol. 199, issue 3, pp. 302-312, 2019 02 01. PMCID: PMC6363971  PMID: 30543455
Younis, U. S., E. Vallorz, K. J. Addison, J. G. Ledford, and P. B. Myrdal, "Preformulation and Evaluation of Tofacitinib as a Therapeutic Treatment for Asthma.", AAPS PharmSciTech, vol. 20, issue 5, pp. 167, 2019 Apr 16. PMCID: PMC6818719  PMID: 30993508
Dy, A. Blythe C., M. Z. Arif, K. J. Addison, L. G. Que, S. Boitano, M. Kraft, and J. G. Ledford, "Genetic Variation in Surfactant Protein-A2 Delays Resolution of Eosinophilia in Asthma.", J Immunol, vol. 203, issue 5, pp. 1122-1130, 2019 09 01. PMCID: PMC6702058  PMID: 31350355
Sandalova, E., J. G. Ledford, M. Baskaran, and S. Dijkstra, "Translational Medicine in the Era of Social Media: A Survey of Scientific and Clinical Communities.", Front Med (Lausanne), vol. 6, pp. 152, 2019. PMCID: PMC6616126  PMID: 31334236

2018

Dy, A. Blythe C., S. Tanyaratsrisakul, D. R. Voelker, and J. G. Ledford, "The Emerging Roles of Surfactant Protein-A in Asthma.", J Clin Cell Immunol, vol. 9, issue 4, 2018. PMCID: PMC6092951  PMID: 30123671
Dijkstra, S., G. Kok, J. G. Ledford, E. Sandalova, and R. Stevelink, "Possibilities and Pitfalls of Social Media for Translational Medicine.", Front Med (Lausanne), vol. 5, pp. 345, 2018. PMCID: PMC6291449  PMID: 30574495
Lugogo, N., D. Francisco, K. J. Addison, A. Manne, W. Pederson, J. L. Ingram, C. L. Green, B. T. Suratt, J. J. Lee, M. E. Sunday, et al., "Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications.", J Allergy Clin Immunol, vol. 141, issue 3, pp. 918-926.e3, 2018 03. PMCID: PMC5732097  PMID: 28624607