Publications
Larrinaga, Tania M, et al. “Lmod2 Is Necessary for Effective Skeletal Muscle Contraction.”. Sci Adv, vol. 10, no. 11, Mar. 2024, p. eadk1890, https://doi.org/10.1126/sciadv.adk1890.
Schultz, Lauren E, et al. “A Nemaline Myopathy-Linked Mutation Inhibits the Actin-Regulatory Functions of Tropomodulin and Leiomodin.”. Proc Natl Acad Sci U S A, vol. 120, no. 47, Nov. 2023, p. e2315820120, https://doi.org/10.1073/pnas.2315820120.
Yuen, Michaela, et al. “Neonatal-Lethal Dilated Cardiomyopathy Due to a Homozygous LMOD2 Donor Splice-Site Variant.”. Eur J Hum Genet, vol. 30, no. 4, Apr. 2022, pp. 450-7, https://doi.org/10.1038/s41431-022-01043-8.
Colpan, Mert, et al. “CAP2 Is a Regulator of Actin Pointed End Dynamics and Myofibrillogenesis in Cardiac Muscle.”. Commun Biol, vol. 4, no. 1, Mar. 2021, p. 365, https://doi.org/10.1038/s42003-021-01893-w.
Tolkatchev, Dmitri, et al. “Leiomodin Creates a Leaky Cap at the Pointed End of Actin-Thin Filaments.”. PLoS Biol, vol. 18, no. 9, Sept. 2020, p. e3000848, https://doi.org/10.1371/journal.pbio.3000848.
Mi-Mi, Lei, et al. “In Vivo Elongation of Thin Filaments Results in Heart Failure.”. PLoS One, vol. 15, no. 1, 2020, p. e0226138, https://doi.org/10.1371/journal.pone.0226138.
Ahrens-Nicklas, Rebecca C, et al. “Disruption of Cardiac Thin Filament Assembly Arising from a Mutation in : A Novel Mechanism of Neonatal Dilated Cardiomyopathy.”. Sci Adv, vol. 5, no. 9, Sept. 2019, p. eaax2066, https://doi.org/10.1126/sciadv.aax2066.
Ly, Thu, et al. “Effects of Cardiomyopathy-Linked Mutations K15N and R21H in Tropomyosin on Thin-Filament Regulation and Pointed-End Dynamics.”. Mol Biol Cell, vol. 30, no. 2, Jan. 2019, pp. 268-81, https://doi.org/10.1091/mbc.E18-06-0406.
Pappas, Christopher T, et al. “Cardiac-Specific Knockout of Lmod2 Results in a Severe Reduction in Myofilament Force Production and Rapid Cardiac Failure.”. J Mol Cell Cardiol, vol. 122, Sept. 2018, pp. 88-97, https://doi.org/10.1016/j.yjmcc.2018.08.009.
Chu, Miensheng, et al. “Increased Cardiac Arrhythmogenesis Associated With Gap Junction Remodeling With Upregulation of RNA-Binding Protein FXR1.”. Circulation, vol. 137, no. 6, Feb. 2018, pp. 605-18, https://doi.org/10.1161/CIRCULATIONAHA.117.028976.
Wu, Tongbin, et al. “HSPB7 Is Indispensable for Heart Development by Modulating Actin Filament Assembly.”. Proc Natl Acad Sci U S A, vol. 114, no. 45, Nov. 2017, pp. 11956-61, https://doi.org/10.1073/pnas.1713763114.
Henderson, Christine A, et al. “Overview of the Muscle Cytoskeleton.”. Compr Physiol, vol. 7, no. 3, June 2017, pp. 891-44, https://doi.org/10.1002/cphy.c160033.
Ly, Thu, et al. “The N-Terminal Tropomyosin- and Actin-Binding Sites Are Important for Leiomodin 2’s Function.”. Mol Biol Cell, vol. 27, no. 16, Aug. 2016, pp. 2565-75, https://doi.org/10.1091/mbc.E16-03-0200.
Winter, Josine M de, et al. “Mutation-Specific Effects on Thin Filament Length in Thin Filament Myopathy.”. Ann Neurol, vol. 79, no. 6, June 2016, pp. 959-69, https://doi.org/10.1002/ana.24654.
Chu, Miensheng, et al. “Nebulin, a Multi-Functional Giant.”. J Exp Biol, vol. 219, no. Pt 2, Jan. 2016, pp. 146-52, https://doi.org/10.1242/jeb.126383.
Pappas, Christopher T, et al. “Knockout of Lmod2 Results in Shorter Thin Filaments Followed by Dilated Cardiomyopathy and Juvenile Lethality.”. Proc Natl Acad Sci U S A, vol. 112, no. 44, Nov. 2015, pp. 13573-8, https://doi.org/10.1073/pnas.1508273112.
Nworu, Chinedu U, et al. “Leiomodin 3 and Tropomodulin 4 Have Overlapping Functions During Skeletal Myofibrillogenesis.”. J Cell Sci, vol. 128, no. 2, Jan. 2015, pp. 239-50, https://doi.org/10.1242/jcs.152702.
Yuen, Michaela, et al. “Leiomodin-3 Dysfunction Results in Thin Filament Disorganization and Nemaline Myopathy.”. J Clin Invest, vol. 124, no. 11, Nov. 2014, pp. 4693-708, https://doi.org/10.1172/JCI75199.
Granzier, Henk L, et al. “Deleting Titin’s I-Band A-Band Junction Reveals Critical Roles for Titin in Biomechanical Sensing and Cardiac Function.”. Proc Natl Acad Sci U S A, vol. 111, no. 40, Oct. 2014, pp. 14589-94, https://doi.org/10.1073/pnas.1411493111.
Bliss, Katherine T, et al. “Investigating Lasp-2 in Cell Adhesion: New Binding Partners and Roles in Motility.”. Mol Biol Cell, vol. 24, no. 7, Apr. 2013, pp. 995-1006, https://doi.org/10.1091/mbc.E12-10-0723.
Leinwand, Leslie A, et al. “Mutations in the Sensitive Giant Titin Result in a Broken Heart”. Circ Res, vol. 111, no. 2, July 2012, pp. 158-61, https://doi.org/10.1161/RES.0b013e3182635ca2.
Donlin, Laura T, et al. “Smyd2 Controls Cytoplasmic Lysine Methylation of Hsp90 and Myofilament Organization.”. Genes Dev, vol. 26, no. 2, Jan. 2012, pp. 114-9, https://doi.org/10.1101/gad.177758.111.
Whitman, Samantha A, et al. “Desmoplakin and Talin2 Are Novel MRNA Targets of Fragile X-Related Protein-1 in Cardiac Muscle.”. Circ Res, vol. 109, no. 3, July 2011, pp. 262-71, https://doi.org/10.1161/CIRCRESAHA.111.244244.
Pappas, Christopher T, et al. “The Nebulin Family: An Actin Support Group.”. Trends Cell Biol, vol. 21, no. 1, Jan. 2011, pp. 29-37, https://doi.org/10.1016/j.tcb.2010.09.005.