Henk Granzier, PhD

Professor, Cellular and Molecular Medicine

Director, Molecular Cardiovascular Research Program

Professor, BIO5 Insitutue

Professor, Biomedical Engineering

Professor, Genetics GIDP

Professor, Molecular and Cellular Biology

Professor, Physiological Sciences GIDP

Professor, Physiology

Lab Phone: (520) 626-4198

granzier@arizona.edu

Links

Degrees

PhD

Teaching Interests

Discovering mechanisms whereby the giant filamentous protein titin influence muscle structure and function.

Publications

Chan, Brandon Y H, et al. “MMP Inhibitors Attenuate Doxorubicin Cardiotoxicity by Preventing Intracellular and Extracellular Matrix Remodelling.”. Cardiovasc Res, vol. 117, no. 1, Jan. 2021, pp. 188-00, https://doi.org/10.1093/cvr/cvaa017.

Lindqvist, Johan, et al. “Triggering Typical Nemaline Myopathy With Compound Heterozygous Nebulin Mutations Reveals Myofilament Structural Changes As Pathomechanism.”. Nat Commun, vol. 11, no. 1, June 2020, p. 2699, https://doi.org/10.1038/s41467-020-16526-9.

Brynnel, Ambjorn, et al. “Downsizing the Molecular Spring of the Giant Protein Titin Reveals That Skeletal Muscle Titin Determines Passive Stiffness and Drives Longitudinal Hypertrophy.”. Elife, vol. 7, Dec. 2018, https://doi.org/10.7554/eLife.40532.

Winter, Josine M de, et al. “Mutation-Specific Effects on Thin Filament Length in Thin Filament Myopathy.”. Ann Neurol, vol. 79, no. 6, June 2016, pp. 959-69, https://doi.org/10.1002/ana.24654.

Pappas, Christopher T, et al. “Knockout of Lmod2 Results in Shorter Thin Filaments Followed by Dilated Cardiomyopathy and Juvenile Lethality.”. Proc Natl Acad Sci U S A, vol. 112, no. 44, Nov. 2015, pp. 13573-8, https://doi.org/10.1073/pnas.1508273112.

Li, Frank, et al. “Nebulin Deficiency in Adult Muscle Causes Sarcomere Defects and Muscle-Type-Dependent Changes in Trophicity: Novel Insights in Nemaline Myopathy.”. Hum Mol Genet, vol. 24, no. 18, Sept. 2015, pp. 5219-33, https://doi.org/10.1093/hmg/ddv243.

Granzier, Henk L, et al. “Deleting Titin’s I-Band A-Band Junction Reveals Critical Roles for Titin in Biomechanical Sensing and Cardiac Function.”. Proc Natl Acad Sci U S A, vol. 111, no. 40, Oct. 2014, pp. 14589-94, https://doi.org/10.1073/pnas.1411493111.

Methawasin, Mei, et al. “Experimentally Increasing Titin Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism But Has a Beneficial Effect on Diastole.”. Circulation, vol. 129, no. 19, May 2014, pp. 1924-36, https://doi.org/10.1161/CIRCULATIONAHA.113.005610.

Anderson, Brian R, et al. “Single Molecule Force Spectroscopy on Titin Implicates Immunoglobulin Domain Stability As a Cardiac Disease Mechanism.”. J Biol Chem, vol. 288, no. 8, Feb. 2013, pp. 5303-15, https://doi.org/10.1074/jbc.M112.401372.

Lee, Eun-Jeong, et al. “Fast Skeletal Muscle Troponin Activation Increases Force of Mouse Fast Skeletal Muscle and Ameliorates Weakness Due to Nebulin-Deficiency.”. PLoS One, vol. 8, no. 2, 2013, p. e55861, https://doi.org/10.1371/journal.pone.0055861.

Doetschman, Thomas, et al. “Transforming Growth Factor Beta Signaling in Adult Cardiovascular Diseases and Repair.”. Cell Tissue Res, vol. 347, no. 1, Jan. 2012, pp. 203-23, https://doi.org/10.1007/s00441-011-1241-3.

Makwana, Om, et al. “Exposure to Low-Dose Trichloroethylene Alters Shear Stress Gene Expression and Function in the Developing Chick Heart.”. Cardiovasc Toxicol, vol. 10, no. 2, June 2010, pp. 100-7, https://doi.org/10.1007/s12012-010-9066-y.

Tonino, Paola, et al. “Reduced Myofibrillar Connectivity and Increased Z-Disk Width in Nebulin-Deficient Skeletal Muscle.”. J Cell Sci, vol. 123, no. Pt 3, Jan. 2010, pp. 384-91, https://doi.org/10.1242/jcs.042234.

Kolb, Justin, et al. “Thin Filament Length in the Cardiac Sarcomere Varies With Sarcomere Length But Is Independent of Titin and Nebulin.”. J Mol Cell Cardiol, vol. 97, pp. 286-94, https://doi.org/10.1016/j.yjmcc.2016.04.013.