Henk Granzier, PhD

Professor, Cellular and Molecular Medicine

Professor, BIO5 Insitutue

Professor, Biomedical Engineering

Professor, Genetics GIDP

Professor, Molecular and Cellular Biology

Professor, Physiological Sciences GIDP

Professor, Physiology

Lab Phone: (520) 626-4198

granzier@arizona.edu

Links

Degrees

PhD

Teaching Interests

Discovering mechanisms whereby the giant filamentous protein titin influence muscle structure and function.

Publications

Chan, Brandon Y H, et al. “MMP Inhibitors Attenuate Doxorubicin Cardiotoxicity by Preventing Intracellular and Extracellular Matrix Remodelling.”. Cardiovasc Res, vol. 117, no. 1, Jan. 2021, pp. 188-00, https://doi.org/10.1093/cvr/cvaa017.

Lindqvist, Johan, et al. “Triggering Typical Nemaline Myopathy With Compound Heterozygous Nebulin Mutations Reveals Myofilament Structural Changes As Pathomechanism.”. Nat Commun, vol. 11, no. 1, June 2020, p. 2699, https://doi.org/10.1038/s41467-020-16526-9.

Brynnel, Ambjorn, et al. “Downsizing the Molecular Spring of the Giant Protein Titin Reveals That Skeletal Muscle Titin Determines Passive Stiffness and Drives Longitudinal Hypertrophy.”. Elife, vol. 7, Dec. 2018, https://doi.org/10.7554/eLife.40532.

Winter, Josine M de, et al. “Mutation-Specific Effects on Thin Filament Length in Thin Filament Myopathy.”. Ann Neurol, vol. 79, no. 6, June 2016, pp. 959-69, https://doi.org/10.1002/ana.24654.

Pappas, Christopher T, et al. “Knockout of Lmod2 Results in Shorter Thin Filaments Followed by Dilated Cardiomyopathy and Juvenile Lethality.”. Proc Natl Acad Sci U S A, vol. 112, no. 44, Nov. 2015, pp. 13573-8, https://doi.org/10.1073/pnas.1508273112.

Li, Frank, et al. “Nebulin Deficiency in Adult Muscle Causes Sarcomere Defects and Muscle-Type-Dependent Changes in Trophicity: Novel Insights in Nemaline Myopathy.”. Hum Mol Genet, vol. 24, no. 18, Sept. 2015, pp. 5219-33, https://doi.org/10.1093/hmg/ddv243.

Granzier, Henk L, et al. “Deleting Titin’s I-Band A-Band Junction Reveals Critical Roles for Titin in Biomechanical Sensing and Cardiac Function.”. Proc Natl Acad Sci U S A, vol. 111, no. 40, Oct. 2014, pp. 14589-94, https://doi.org/10.1073/pnas.1411493111.

Methawasin, Mei, et al. “Experimentally Increasing Titin Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism But Has a Beneficial Effect on Diastole.”. Circulation, vol. 129, no. 19, May 2014, pp. 1924-36, https://doi.org/10.1161/CIRCULATIONAHA.113.005610.

Anderson, Brian R, et al. “Single Molecule Force Spectroscopy on Titin Implicates Immunoglobulin Domain Stability As a Cardiac Disease Mechanism.”. J Biol Chem, vol. 288, no. 8, Feb. 2013, pp. 5303-15, https://doi.org/10.1074/jbc.M112.401372.

Lee, Eun-Jeong, et al. “Fast Skeletal Muscle Troponin Activation Increases Force of Mouse Fast Skeletal Muscle and Ameliorates Weakness Due to Nebulin-Deficiency.”. PLoS One, vol. 8, no. 2, 2013, p. e55861, https://doi.org/10.1371/journal.pone.0055861.

Doetschman, Thomas, et al. “Transforming Growth Factor Beta Signaling in Adult Cardiovascular Diseases and Repair.”. Cell Tissue Res, vol. 347, no. 1, Jan. 2012, pp. 203-23, https://doi.org/10.1007/s00441-011-1241-3.

Makwana, Om, et al. “Exposure to Low-Dose Trichloroethylene Alters Shear Stress Gene Expression and Function in the Developing Chick Heart.”. Cardiovasc Toxicol, vol. 10, no. 2, June 2010, pp. 100-7, https://doi.org/10.1007/s12012-010-9066-y.

Tonino, Paola, et al. “Reduced Myofibrillar Connectivity and Increased Z-Disk Width in Nebulin-Deficient Skeletal Muscle.”. J Cell Sci, vol. 123, no. Pt 3, Jan. 2010, pp. 384-91, https://doi.org/10.1242/jcs.042234.

Kolb, Justin, et al. “Thin Filament Length in the Cardiac Sarcomere Varies With Sarcomere Length But Is Independent of Titin and Nebulin.”. J Mol Cell Cardiol, vol. 97, pp. 286-94, https://doi.org/10.1016/j.yjmcc.2016.04.013.