John Edward Smith, III, PhD

Research Associate

Granzier Lab

Lab Room Number: MRB 340

jes3@arizona.edu

Links

Education: 2002 Ph.D. Biology University of Virginia Charlottesville, VA 1987 B.S. Cellular & Developmental Biology The University of Arizona Tucson, AZ Experience: 2010-present; Research Associate; Cellular & Molecular Medicine; The University of Arizona; Tucson, AZ 2009-2010; Adjunct Instructor; Biology Department; Howard University; Washington, DC 2005-2009; Postdoctoral Fellow; Lab of Cellular & Developmental Biology; NIDDK/NIH; Bethesda, MD 2002-2005; Research Molecular Biologist; Biotechnology & Germplasm Lab; Agricultural Research Service, USDA; Beltsville, MD Publications: https://www.ncbi.nlm.nih.gov/myncbi/john.smith.1/bibliography/public/ https://orcid.org/0000-0002-0888-1274 https://www.scopus.com/authid/detail.uri?authorId=55782720500 https://publons.com/researcher/1671640/john-smith/

Degrees

Ph.D. Biology University of Virginia
B.S. Cellular & Developmental Biology The University of Arizona

Publications

Lindqvist, Johan, et al. “Triggering Typical Nemaline Myopathy With Compound Heterozygous Nebulin Mutations Reveals Myofilament Structural Changes As Pathomechanism.”. Nat Commun, vol. 11, no. 1, June 2020, p. 2699, https://doi.org/10.1038/s41467-020-16526-9.

Brynnel, Ambjorn, et al. “Downsizing the Molecular Spring of the Giant Protein Titin Reveals That Skeletal Muscle Titin Determines Passive Stiffness and Drives Longitudinal Hypertrophy.”. Elife, vol. 7, Dec. 2018, https://doi.org/10.7554/eLife.40532.

Li, Frank, et al. “Nebulin Deficiency in Adult Muscle Causes Sarcomere Defects and Muscle-Type-Dependent Changes in Trophicity: Novel Insights in Nemaline Myopathy.”. Hum Mol Genet, vol. 24, no. 18, Sept. 2015, pp. 5219-33, https://doi.org/10.1093/hmg/ddv243.

Granzier, Henk L, et al. “Deleting Titin’s I-Band A-Band Junction Reveals Critical Roles for Titin in Biomechanical Sensing and Cardiac Function.”. Proc Natl Acad Sci U S A, vol. 111, no. 40, Oct. 2014, pp. 14589-94, https://doi.org/10.1073/pnas.1411493111.

Methawasin, Mei, et al. “Experimentally Increasing Titin Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism But Has a Beneficial Effect on Diastole.”. Circulation, vol. 129, no. 19, May 2014, pp. 1924-36, https://doi.org/10.1161/CIRCULATIONAHA.113.005610.