Kelvin Pond, PhD

Assistant Research Professor, Cellular and Molecular Medicine (Research Series Track) (Career Track)

Lab Phone: 520-621-0022

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Dr. Kelvin Pond is an Assistant Research Professor at the University of Arizona's Department of Cellular and Molecular Medicine, where he is developing patient-derived organoid technology to advance the understanding of epithelial homeostasis and single-cell kinase dynamics. His research, which integrates collaboration with machine learning specialists and bioengineers, focuses on DNA repair, genomic instability, and the development of innovative therapeutic solutions. Dr. Pond is actively establishing a new lab dedicated to these efforts. As a Wellcome Trust Researcher and recipient of the 2023 FASEB Outstanding New Investigator Award, he is committed to mentoring emerging scientists and driving novel biotech research.

Publications

Mallick, Saptarshi, et al. “Genetically Engineered Human Pituitary Corticotroph Tumor Organoids Exhibit Divergent Responses to Glucocorticoid Receptor Modulators.”. Transl Res, vol. 256, June 2023, pp. 56-72, https://doi.org/10.1016/j.trsl.2023.01.002.

Lasick, Kathleen A, et al. “FOXO Nuclear Shuttling Dynamics Are Stimulus-Dependent and Correspond With Cell Fate.”. Mol Biol Cell, vol. 34, no. 3, Mar. 2023, p. ar21, https://doi.org/10.1091/mbc.E22-05-0193.

Cantoria, Mary Jo, et al. “Feedback in the β-Catenin Destruction Complex Imparts Bistability and Cellular Memory.”. Proc Natl Acad Sci U S A, vol. 120, no. 2, Jan. 2023, p. e2208787120, https://doi.org/10.1073/pnas.2208787120.

Pond, Kelvin W, et al. “Live-Cell Imaging in Human Colonic Monolayers Reveals ERK Waves Limit the Stem Cell Compartment to Maintain Epithelial Homeostasis”. Elife, vol. 11, Dec. 2022.

Chakrabarti, Jayati, et al. “Development of Human Pituitary Neuroendocrine Tumor Organoids to Facilitate Effective Targeted Treatments of Cushing’s Disease.”. Cells, vol. 11, no. 21, Oct. 2022, https://doi.org/10.3390/cells11213344.

Chakrabarti, J T, et al. “A Novel Human Pituitary Adenoma Model to Accelerate Targeted Treatment of Cushing’s Disease”. J Neurol Surg, 2022.

de Renty, Christelle, et al. “BLM Sumoylation Is Required for Replication Stability and Normal Fork Velocity During DNA Replication.”. Front Mol Biosci, vol. 9, 2022, p. 875102, https://doi.org/10.3389/fmolb.2022.875102.

Pond, Kelvin W, et al. “Wnt/β-Catenin/Signaling/in/Tissue/Self-Organization.”. Genes (Basel), vol. 11, no. 8, Aug. 2020, https://doi.org/10.3390/genes11080939.

Pond, Kelvin W, and Ellis, Nathan A. “Quantification of Double-Strand Breaks in Mammalian Cells Using Pulsed-Field Gel Electrophoresis.”. Methods Mol Biol, vol. 1999, May 2019, pp. 75-85, https://doi.org/10.1007/978-1-4939-9500-4_4.

Pond, Kelvin W, et al. “Rescue of Collapsed Replication Forks Is Dependent on NSMCE2 to Prevent Mitotic DNA Damage.”. PLoS Genet, vol. 15, no. 2, Feb. 2019, p. e1007942, https://doi.org/10.1371/journal.pgen.1007942.

Harryman, William L, et al. “Targeting the Cohesive Cluster Phenotype in Chordoma via β1 Integrin Increases Ionizing Radiation Efficacy.”. Neoplasia, vol. 19, no. 11, Nov. 2017, pp. 919-27, https://doi.org/10.1016/j.neo.2017.08.005.

Harryman, William L, et al. “Laminin-Binding Integrin Gene Copy Number Alterations in Distinct Epithelial-Type Cancers.”. Am J Transl Res, vol. 8, no. 2, 2016, pp. 940-54.

Geffre, Christopher P, et al. “Combined Micro CT and Histopathology for Evaluation of Skeletal Metastasis in Live Animals.”. Am J Transl Res, vol. 7, no. 2, 2015, pp. 348-55.

Samulitis, Betty K, et al. “Gemcitabine Resistant Pancreatic Cancer Cell Lines Acquire an Invasive Phenotype With Collateral Hypersensitivity to Histone Deacetylase Inhibitors.”. Cancer Biol Ther, vol. 16, no. 1, 2015, pp. 43-51, https://doi.org/10.4161/15384047.2014.986967.

Landowski, Terry H, et al. “Targeting Integrin α6 Stimulates Curative-Type Bone Metastasis Lesions in a Xenograft Model.”. Mol Cancer Ther, vol. 13, no. 6, June 2014, pp. 1558-66, https://doi.org/10.1158/1535-7163.MCT-13-0962.

Chauhan, S, et al. “Characterization of the Ferm Domain Protein EHM2 in Human Cancer Cells”. Cell Adhesion and Cytoskeletal Molecules in Metastasis, 2006.

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Kelvin Pond, PhD

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Publications