Ritu Pandey, PhD

Associate Professor, Cellular and Molecular Medicine (Research Track)

Associate Director, Translational Clinical Bioinformatics

ritu@arizona.edu

Degrees

PhD, MHM

Teaching Interests

Investigating the underlying molecular profiles in cancer patient data using integrated computational analysis of multi-omics data in the context of disease outcome, treatment and progression.

Research Interests

Data driven research. Our interest is to investigate underlying molecular events in tumor cohorts by integrated computational analysis of clinical and molecular data from multi-omics projects. Translate the datasets into insights that advance understanding of biomarkers/therapeutic targets and response to treatment. Current focus is to evaluate stratified patient populations for transcriptome, proteome and immune signatures in colorectal tumor with specific gene mutations.

Publications

Morrison, Christopher, et al. “Gene Expression Patterns Associated With Survival in Glioblastoma.”. Int J Mol Sci, vol. 25, no. 7, Mar. 2024, https://doi.org/10.3390/ijms25073668.

Lou, Emil, et al. “Differential Landscape of Immune Evasion in Oncogenic RAS-Driven Primary and Metastatic Colorectal Cancers.”. Mol Ther Oncol, vol. 32, no. 1, Mar. 2024, p. 200786, https://doi.org/10.1016/j.omton.2024.200786.

Song, Heyu, et al. “High-Fat Diet Plus HNF1A Variant Promotes Polyps by Activating β-Catenin in Early-Onset Colorectal Cancer.”. JCI Insight, vol. 8, no. 13, July 2023, https://doi.org/10.1172/jci.insight.167163.

Batai, Ken, et al. “Clear Cell Renal Cell Carcinoma Molecular Variations in Non-Hispanic White and Hispanic Patients.”. Cancer Med, vol. 12, no. 11, June 2023, pp. 12792-01, https://doi.org/10.1002/cam4.5929.

Chakrabarti, Jayati, et al. “Development of Human Pituitary Neuroendocrine Tumor Organoids to Facilitate Effective Targeted Treatments of Cushing’s Disease.”. Cells, vol. 11, no. 21, Oct. 2022, https://doi.org/10.3390/cells11213344.

Singh, Neha, et al. “The Long Noncoding RNA H19 Regulates Tumor Plasticity in Neuroendocrine Prostate Cancer.”. Nat Commun, vol. 12, no. 1, Dec. 2021, p. 7349, https://doi.org/10.1038/s41467-021-26901-9.

Rico, Karen, et al. “Genome Analysis Identifies Differences in the Transcriptional Targets of Duodenal versus Pancreatic Neuroendocrine Tumours.”. BMJ Open Gastroenterol, vol. 8, no. 1, Nov. 2021, https://doi.org/10.1136/bmjgast-2021-000765.

Wusterbarth, Emily, et al. “Cartilage Oligomeric Matrix Protein, COMP May Be a Better Prognostic Marker Than CEACAM5 and Correlates With Colon Cancer Molecular Subtypes, Tumor Aggressiveness and Overall Survival.”. J Surg Res, vol. 270, Oct. 2021, pp. 169-77, https://doi.org/10.1016/j.jss.2021.09.007.

Pandey, Ritu, et al. “Molecular Pathways Associated With Kallikrein 6 Overexpression in Colorectal Cancer.”. Genes (Basel), vol. 12, no. 5, May 2021, https://doi.org/10.3390/genes12050749.

Cheng, Julia N, et al. “A Role for TGFβ Signaling in Preclinical Osteolytic Estrogen Receptor-Positive Breast Cancer Bone Metastases Progression.”. Int J Mol Sci, vol. 22, no. 9, Apr. 2021, https://doi.org/10.3390/ijms22094463.

Pandey, Ritu, et al. “Mutations As a Driver of Metastasis Signaling in Advanced Cancer Patients.”. Cancers (Basel), vol. 13, no. 4, Feb. 2021, https://doi.org/10.3390/cancers13040597.

Iesa, Mohamed Am, et al. “SARS-COV2 and Common Immunodominant Regions May Explain Low COVID-19 Incidence in the Malaria-Endemic Belt.”. New Microbes New Infect, Nov. 2020, p. 100817, https://doi.org/10.1016/j.nmni.2020.100817.

Larson, Kristian, et al. “A Comparative Analysis of Tumors and Plasma Circulating Tumor DNA in 145 Advanced Cancer Patients Annotated by 3 Core Cellular Processes.”. Cancers (Basel), vol. 12, no. 3, Mar. 2020, https://doi.org/10.3390/cancers12030701.

Singh, Neha, et al. “PIM Protein Kinases Regulate the Level of the Long Noncoding RNA H19 to Control Stem Cell Gene Transcription and Modulate Tumor Growth.”. Mol Oncol, Mar. 2020, https://doi.org/10.1002/1878-0261.12662.

Pandey, Ritu, et al. “Carcinoembryonic Antigen Cell Adhesion Molecule 6 (CEACAM6) in Pancreatic Ductal Adenocarcinoma (PDA): An Integrative Analysis of a Novel Therapeutic Target.”. Sci Rep, vol. 9, no. 1, Dec. 2019, p. 18347, https://doi.org/10.1038/s41598-019-54545-9.

Chen, Hwudaurw, et al. “Kallikrein 6 Protease Advances Colon Tumorigenesis Induction of the High Mobility Group A2 Protein.”. Oncotarget, vol. 10, no. 58, Oct. 2019, pp. 6062-78, https://doi.org/10.18632/oncotarget.27153.

Song, Jin H, et al. “Small-Molecule-Targeting Hairpin Loop of HTERT Promoter G-Quadruplex Induces Cancer Cell Death.”. Cell Chem Biol, May 2019, https://doi.org/10.1016/j.chembiol.2019.04.009.

Pandey, Ritu, et al. “Circulating MiRNA Profiling of Women at High Risk for Ovarian Cancer.”. Transl Oncol, vol. 12, no. 5, May 2019, pp. 714-25, https://doi.org/10.1016/j.tranon.2019.01.006.

Sells, Earlphia, et al. “Specific MicroRNA-MRNA Regulatory Network of Colon Cancer Invasion Mediated by Tissue Kallikrein-Related Peptidase 6.”. Neoplasia, vol. 19, no. 5, May 2017, pp. 396-11, https://doi.org/10.1016/j.neo.2017.02.003.