Shanna Hamilton, PhD
BSc Biochemistry, Swansea University, 2012
PhD Medicine/Biophysics, Cardiff University, 2018
Postdoctoral Training in Cardiovascular Physiology, Brown University, 2018-2019
Postdoctoral Training in Cardiovascular Physiology, The Ohio State University, 2019-2023
Teaching Interests
Discovering molecular mechanisms that regulate calcium handling and contribute to arrhythmogenesis in the diseased heart.
Research Interests
Abnormal calcium handling in the heart is implicated in many cardiovascular diseases and contributes to cardiac arrhythmias and sudden cardiac death. The overarching goal of our laboratory is to decipher molecular mechanisms regulating calcium handling in the healthy and diseased heart. This will uncover new therapeutic approaches that we can test to prevent these arrhythmias and treat heart disease.
We integrate a combination of confocal microscopy, electrophysiology, ex vivo whole heart optical mapping and gene editing approaches to study these mechanisms in multiple rodent models of cardiac diseases, from molecule-cell-organ-organism. This includes models of inherited heart disease (catecholaminergic polymorphic ventricular tachycardia; CPVT) and models of acquired heart disease (myocardial infarct, hypertrophy and heart failure, aging, diabetes, atrial arrhythmia).