Kelvin Pond, PhD

Assistant Research Professor, Cellular and Molecular Medicine (Research Series Track) (Career Track)

Dr. Kelvin Pond is an Assistant Research Professor at the University of Arizona's Department of Cellular and Molecular Medicine, where he is developing patient-derived organoid technology to advance the understanding of epithelial homeostasis and single-cell kinase dynamics. His research, which integrates collaboration with machine learning specialists and bioengineers, focuses on DNA repair, genomic instability, and the development of innovative therapeutic solutions. Dr. Pond is actively establishing a new lab dedicated to these efforts. As a Wellcome Trust Researcher and recipient of the 2023 FASEB Outstanding New Investigator Award, he is committed to mentoring emerging scientists and driving novel biotech research.

Molecular Medicine Grad Program: 
Yes

Bibliography

2023

Lasick, K. A., E. Jose, A. M. Samayoa, L. Shanks, K. W. Pond, C. A. Thorne, and A. L. Paek, "FOXO nuclear shuttling dynamics are stimulus-dependent and correspond with cell fate.", Mol Biol Cell, vol. 34, issue 3, pp. ar21, 2023 Mar 01. PMCID: PMC10011729  PMID: 36735481
Mallick, S., J. Chakrabarti, J. Eschbacher, A. G. Moraitis, A. E. Greenstein, J. Churko, K. W. Pond, A. Livolsi, C. A. Thorne, A. S. Little, et al., "Genetically engineered human pituitary corticotroph tumor organoids exhibit divergent responses to glucocorticoid receptor modulators.", Transl Res, vol. 256, pp. 56-72, 2023 Jun. PMID: 36640905
Cantoria, M. Jo, E. Alizadeh, J. Ravi, R. P. Varghese, N. Bunnag, K. W. Pond, A. N. Kettenbach, Y. Ahmed, A. L. Paek, J. J. Tyson, et al., "Feedback in the β-catenin destruction complex imparts bistability and cellular memory.", Proc Natl Acad Sci U S A, vol. 120, issue 2, pp. e2208787120, 2023 Jan 10. PMCID: PMC9926258  PMID: 36598937

2022

Chakrabarti, J., R. Pandey, J. M. Churko, J. Eschbacher, S. Mallick, Y. Chen, B. Hermes, P. Mallick, B. N. Stansfield, K. W. Pond, et al., "Development of Human Pituitary Neuroendocrine Tumor Organoids to Facilitate Effective Targeted Treatments of Cushing's Disease.", Cells, vol. 11, issue 21, 2022 Oct 23. PMCID: PMC9659185  PMID: 36359740
de Renty, C., K. W. Pond, M. K. Yagle, and N. A. Ellis, "BLM Sumoylation Is Required for Replication Stability and Normal Fork Velocity During DNA Replication.", Front Mol Biosci, vol. 9, pp. 875102, 2022. PMCID: PMC9284272  PMID: 35847987
Pond, K. W., J. M. Morris, O. Alkhimenok, R. P. Varghese, C. R. Cabel, N. A. Ellis, J. Chakrabarti, Y. Zavros, J. L. Merchant, C. A. Thorne, et al., "Live-cell imaging in human colonic monolayers reveals ERK waves limit the stem cell compartment to maintain epithelial homeostasis.", Elife, vol. 11, 12/2022.
Chakrabarti, J. T., J. Eschbacher, S. Mallick, Y. Chen, B. Hermes, P. Mallick, K. W. Pond, C. A. Thorne, K. Yuen, A. Little, et al., "A Novel Human Pituitary Adenoma Model to Accelerate Targeted Treatment of Cushing's Disease", J Neurol Surg, 2022.

2020

Pond, K. W., K. Doubrovinski, and C. A. Thorne, "Wnt/β-catenin Signaling in Tissue Self-Organization.", Genes (Basel), vol. 11, issue 8, 2020 08 14. PMCID: PMC7464740  PMID: 32823838

2019

Pond, K. W., and N. A. Ellis, "Quantification of Double-Strand Breaks in Mammalian Cells Using Pulsed-Field Gel Electrophoresis.", Methods Mol Biol, vol. 1999, pp. 75-85, 2019 05 25. PMID: 31127570
Pond, K. W., C. de Renty, M. K. Yagle, and N. A. Ellis, "Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage.", PLoS Genet, vol. 15, issue 2, pp. e1007942, 2019 02 01. PMCID: PMC6383951  PMID: 30735491

2017

Harryman, W. L., J. M. C. Gard, K. W. Pond, S. J. Simpson, L. H. Heppner, D. Hernandez-Cortes, A. S. Little, J. M. Eschbacher, and A. E. Cress, "Targeting the Cohesive Cluster Phenotype in Chordoma via β1 Integrin Increases Ionizing Radiation Efficacy.", Neoplasia, vol. 19, issue 11, pp. 919-927, 2017 Nov. PMCID: PMC5614733  PMID: 28954241

2015

Samulitis, B. K., K. W. Pond, E. Pond, A. E. Cress, H. Patel, L. Wisner, C. Patel, R. T. Dorr, and T. H. Landowski, "Gemcitabine resistant pancreatic cancer cell lines acquire an invasive phenotype with collateral hypersensitivity to histone deacetylase inhibitors.", Cancer Biol Ther, vol. 16, issue 1, pp. 43-51, 2015. PMCID: PMC4623403  PMID: 25485960

2006

Chauhan, S., R. Childers, J. Himes, A. Pierce, S. Sykes, K. W. Pond, S. Kunz, and R. L. Miesfeld, "Characterization of the Ferm domain protein EHM2 in Human Cancer Cells", Cell Adhesion and Cytoskeletal Molecules in Metastasis, 2006.