Reference
Karra, Aroon S, et al. “A Kinase Divided”. Cancer Cell, vol. 28, no. 2, Aug. 2015, pp. 145-7, https://doi.org/10.1016/j.ccell.2015.07.008.
Abstract
In this issue of Cancer Cell, Herrero and colleagues identify an anti-tumorigenic small molecule that blocks ERK dimerization, but neither its catalytic activity nor its phosphorylation by MEK. These findings demonstrate that targeting protein dimerization could be a therapeutic avenue for inhibiting kinase signaling pathways associated with lower drug resistance.