Reference
Bennett, Brian J, et al. “Network-Centered View of Coronary Artery Disease”. Expert Rev Cardiovasc Ther, vol. 5, no. 6, Nov. 2007, pp. 1095-103, https://doi.org/10.1586/14779072.5.6.1095.
Abstract
Systems biology is an emerging field that attempts to examine multiple elements of a biologic system using techniques such as expression microarrays or proteomics. The goal of systems biology is to detect all the elements of a system and create an interaction network between these so that the system can be explained under specified conditions. In this review we discuss how systems-based approaches are being applied to cardiovascular disease, illustrating concepts, such as the integration of orthogonal datasets, coexpression networks and emergent properties.