Jean Wilson, PhD

Professor, Cellular and Molecular Medicine

Director, Willed Body Program

Professor, BIO5 Institute

Professor, Cancer Biology GIDP

Professor, Neuroscience GIDP

Office Room Number: LSN 459
Lab Phone: (520) 626-2158

(520) 626-2557

jeanw@arizona.edu

Documents

Links

Bibliography

Degrees

Teaching Interests

The Wilson laboratory works on the establishment and maintenance of the integrity of the intestine through the regulation of membrane trafficking to the apical plasma membrane domain.

Research Interests

The ability of the epithelial cells to serve as a selective barrier to pathogens while absorbing nutrients is fundamental to their function. Tight junctions and associated polarity complexes are critical for selective permeability and maintenance of epithelial polarity. Our investigations of epithelial development and polarity focus on membrane trafficking to the junctions and apical membrane.

Publications

Clements, Amber N, et al. “Inhibition of PIM Kinase in Tumor-Associated Macrophages Suppresses Inflammasome Activation and Sensitizes Prostate Cancer to Immunotherapy.”. Cancer Immunol Res, vol. 13, no. 5, May 2025, pp. 633-45, https://doi.org/10.1158/2326-6066.CIR-24-0591.

Wu, Meng-Han, et al. “Proliferation in the Developing Intestine Is Regulated by the Endosomal Protein Endotubin.”. Dev Biol, vol. 480, Dec. 2021, pp. 50-61, https://doi.org/10.1016/j.ydbio.2021.08.009.

Jamwal, Deepa R, et al. “Intestinal Epithelial Expression of MHCII Determines Severity of Chemical, T-Cell-Induced, and Infectious Colitis in Mice.”. Gastroenterology, vol. 159, no. 4, Oct. 2020, pp. 1342-1356.e6, https://doi.org/10.1053/j.gastro.2020.06.049.

Blum, Isabella R, et al. “Rab22a Regulates the Establishment of Epithelial Polarity.”. Small GTPases, Apr. 2020, pp. 1-12, https://doi.org/10.1080/21541248.2020.1754104.

Engevik, Amy C, et al. “Loss of Myosin Vb Promotes Apical Bulk Endocytosis in Neonatal Enterocytes.”. J Cell Biol, vol. 218, no. 11, Nov. 2019, pp. 3647-62, https://doi.org/10.1083/jcb.201902063.

Noto, Jennifer M, et al. “Carcinogenic Strains Selectively Dysregulate the Gastric Proteome, Which May Be Associated With Stomach Cancer Progression.”. Mol Cell Proteomics, vol. 18, no. 2, Feb. 2019, pp. 352-71, https://doi.org/10.1074/mcp.RA118.001181.

Cox, Christopher M, et al. “The Endosomal Protein Endotubin Is Required for Enterocyte Differentiation.”. Cell Mol Gastroenterol Hepatol, vol. 5, no. 2, Jan. 2018, pp. 145-56, https://doi.org/10.1016/j.jcmgh.2017.11.001.

Johnson, Debra L, et al. “Arf6 and Rab22 Mediate T Cell Conjugate Formation by Regulating Clathrin-Independent Endosomal Membrane Trafficking.”. J Cell Sci, June 2017, https://doi.org/10.1242/jcs.200477.

Parker, Sara S, et al. “Rabs Set the Stage for Polarity.”. Small GTPases, Jan. 2017, pp. 1-14, https://doi.org/10.1080/21541248.2016.1277840.

Lu, Ruifeng, and Wilson, Jean M. “Rab14 Specifies the Apical Membrane through Arf6-Mediated Regulation of Lipid Domains and Cdc42.”. Sci Rep, vol. 6, Nov. 2016, p. 38249, https://doi.org/10.1038/srep38249.

Cox, Christopher M, et al. “Endosomal Regulation of Contact Inhibition through the AMOT:YAP Pathway.”. Mol Biol Cell, vol. 26, no. 14, July 2015, pp. 2673-84, https://doi.org/10.1091/mbc.E15-04-0224.

Lu, Ruifeng, et al. “Scaffolding Protein GOPC Regulates Tight Junction Structure.”. Cell Tissue Res, vol. 360, no. 2, May 2015, pp. 321-32, https://doi.org/10.1007/s00441-014-2088-1.

Lu, Ruifeng, et al. “PKCι Interacts With Rab14 and Modulates Epithelial Barrier Function through Regulation of Claudin-2 Levels.”. Mol Biol Cell, vol. 26, no. 8, Apr. 2015, pp. 1523-31, https://doi.org/10.1091/mbc.E14-12-1613.

Romanoski, Casey E, et al. “Epigenomics: Roadmap for Regulation”. Nature, vol. 518, no. 7539, Feb. 2015, pp. 314-6, https://doi.org/10.1038/518314a.

Cox, C.M., et al. Endosomal Regulation of Contact Inhibition through the AMOT:YAP Pathway. 2015.

Lu, R., et al. Rab14 Regulates Epithelial Lumen Morphogenesis through Regulation of Claudin-2 Trafficking. Molec Biol Cell 25:1744-54. 2014.

Parker, Sara S, et al. “Competing Molecular Interactions of APKC Isoforms Regulate Neuronal Polarity.”. Proc Natl Acad Sci U S A, vol. 110, no. 35, Aug. 2013, pp. 14450-5, https://doi.org/10.1073/pnas.1301588110.

McCarter, S, et al. Regulation of Tight Junction Assembly and Epithelial Polarity by a Resident Protein of Apical Endosomes. Traffic 11:856-866. Jan. 2010.

Kitt, Khameeka N, et al. “Rab14 Regulates Apical Targeting in Polarized Epithelial Cells.”. Traffic, vol. 9, no. 7, July 2008, pp. 1218-31, https://doi.org/10.1111/j.1600-0854.2008.00752.x.

Kitt, KN, et al. The Small GTPase Rab 14 Regulates Apical Targeting. Traffic 9:1218-1231. Jan. 2008.

Hernández-Deviez, Delia, et al. “A Role for ARF6 and ARNO in the Regulation of Endosomal Dynamics in Neurons.”. Traffic, vol. 8, no. 12, Dec. 2007, pp. 1750-64, https://doi.org/10.1111/j.1600-0854.2007.00649.x.

Hernández-Deviez, Delia J, et al. “ARNO and ARF6 Regulate Axonal Elongation and Branching through Downstream Activation of Phosphatidylinositol 4-Phosphate 5-Kinase Alpha.”. Mol Biol Cell, vol. 15, no. 1, Jan. 2004, pp. 111-20, https://doi.org/10.1091/mbc.E03-06-0410.

Hernández-Deviez, Delia J, et al. “Regulation of Dendritic Development by the ARF Exchange Factor ARNO.”. Nat Neurosci, vol. 5, no. 7, July 2002, pp. 623-4, https://doi.org/10.1038/nn865.

Gokay, K E, et al. “Cytoplasmic Signals Mediate Apical Early Endosomal Targeting of Endotubin in MDCK Cells.”. Traffic, vol. 2, no. 7, 2001, pp. 487-00.

Wilson, J M, et al. “EEA1, a Tethering Protein of the Early Sorting Endosome, Shows a Polarized Distribution in Hippocampal Neurons, Epithelial Cells, and Fibroblasts.”. Mol Biol Cell, vol. 11, no. 8, Aug. 2000, pp. 2657-71.

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